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Special Issue "Modulation of Protein Structure and Function by Lipids"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 September 2021.

Special Issue Editor

Dr. Avia Rosenhouse-Dantsker
E-Mail Website
Guest Editor
Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA
Interests: structure–function relationship in proteins; protein–lipid interactions; lipid modulation of protein function; modulation of ion channel function; atrial and neuronal G protein-gated inwardly rectifying potassium channels; cholesterol; phosphoinositides; fatty acids

Special Issue Information

Dear Colleagues,

Since the introduction of the fluid mosaic model of cell membrane structure by Singer and Nicolson in 1972, our understanding of the roles of lipids in cellular functions has evolved significantly. Through insights gained with advances in technology, it has become clear that lipids are not merely passive entities that diffuse freely within membrane bilayers but are also key players in the modulation of protein function. Lipids, such as phosphoinositides, sterols, and fatty acids, have been shown to affect the function of a growing number of proteins (e.g., G protein-coupled receptors, ion channels, transporters, etc.). Lipids exert their effect on proteins through a variety of mechanisms, such as by modulating protein structure, function, and dynamics; promoting protein oligomerization; and mediating protein–protein interactions in the membrane. As a result, lipids have emerged as central players in diverse disease processes and, hence, in drug development, where lipid-regulated proteins are potential drug targets. The aim of this Special Issue is to provide an overview of the current understanding of the impact of lipids on protein structure and function in addition to presenting new developments in this field. Both original papers and reviews on this topic are welcome.

Dr. Avia Rosenhouse-Dantsker
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • protein modulation by lipids
  • phosphoinositides
  • cholesterol
  • sterols
  • fatty acids
  • G protein-coupled receptors
  • ion channels
  • transporters

Published Papers

This special issue is now open for submission.
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