Special Issue "Neuronal Protein Homeostasis in Health and Disease"
Deadline for manuscript submissions: closed (30 June 2017).
Interests: nerve injury and neuropathic pain; pain and aging; central adaptations to chronic pain; multiple sclerosis; neuroinflammation; neuro-immunologic communication; redox signaling; nitric oxide; endocannabinoids and other lipid signaling molecules; progranulin; autophagy
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Protein homeostasis is crucial for the maintenance of neuronal integrity and functions. Disturbances are associated with premature aging, neurodegenerative and neuropsychiatric diseases or inability to adapt to mild stresses. Such defects may be caused by pathological aggregrate-prone proteins, such as α synuclein, but, more frequently, subtle changes progressively develop because of inefficient protein folding or removal pathways involving, e.g., chaperones, proteins of the autophagy machinery, or ubiquitin ligases. The protein balance is particularly challenged under stress imposed by, e.g., ischemia, nutrient deficiency, metabolic damage, infection, inflammation, axonal trauma, or immune attack, because ER stress may enhance mis-folding, and enhanced loads of damaged proteins need to be removed to allow for regeneration and renewal. The major degradation systems include proteasome-mediated degradation, autophagy, chaperone mediated autophagy, specific ubiquitin-dependent autophagy, aggrephagy or exosomal release, which may all contribute to preconditioning adaptations during mild stress or endogenous repair after injury. In the present Special Issue, we invite contributions related to protein homeostasis in neurons and neurological diseases.
Prof. Dr. Irmgard Tegeder
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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- ER stress
- Protein aggregate
- Nerve injury
- Protein folding