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Special Issue "Tracking Back Proteotoxicity in Neurodegenerative Diseases"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editors

Prof. Dr. Lucio Tremolizzo
E-Mail Website
Guest Editor
1. School of Medicine and Surgery, Milan Center for Neuroscience (NeuroMI), University of Milano-Bicocca, Monza (MB), Italy
2. Departmentof Neurology, San Gerardo Hospital, Monza (MB), Italy
Interests: neurodegenerative diseases; amyotrophic lateral sclerosis; dementia, oxidative stress; excitotoxicity; peripheral cells; biomarkers
Special Issues and Collections in MDPI journals
Dr. Gessica Sala
E-Mail Website
Guest Editor
Milan Center for Neuroscience (NeuroMI), University of Milano-Bicocca, Monza (MB), Italy
Interests: neurodegenerative diseases; Parkinson’s disease; chaperone-mediated autophagy; macroautophagy; oxidative stress; excitotoxicity; peripheral cells; biomarkers
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Many neurodegenerative diseases including Parkinson’s disease (PD), Alzheimer’s disease (AD), and amyotrophic lateral sclerosis (ALS) belong to the large category of proteinopathies, conditions characterized by the presence of proteinaceous inclusions within and/or outside the degenerating neurons. The identification of such aggregates supports the view that misfolded proteins represent a basic requirement for the neurodegenerative process and provides input to verify the existence of possible dysfunctions of the biological systems influencing protein homeostasis.

In neurodegenerative diseases, both environmental and genetic factors contribute to altering the physiological processes involved in the synthesis of disease-specific proteins, resulting in a protein overproduction or in the generation of post-translationally modified protein forms more prone to aggregation. Furthermore, the impairment of intracellular protein catabolic systems plays a crucial role in proteotoxicity, and the prion-like spreading of pathological proteins further amplifies neuronal damage.

A better comprehension of the molecular mechanisms responsible for proteotoxicity in neurodegenerative diseases can allow the identification of both new therapeutic targets and useful biomarkers for these devastating disorders.

Prof. Dr. Lucio Tremolizzo
Dr. Gessica Sala
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Parkinson’s disease
  • amyotrophic lateral sclerosis
  • Alzheimer’s disease
  • neurodegenerative diseases
  • alpha-synuclein
  • TDP-43
  • beta-amyloid
  • tau
  • genetics
  • catabolism
  • proteotoxicity

Published Papers

This special issue is now open for submission.
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