Special Issue "Puberty and Its Disorders: From Neuro-Regulation of Puberty Onset to Molecular Basis and Management of Pubertal Disorders"
Deadline for manuscript submissions: closed (31 August 2021).
Interests: disorders/differences of sex development (DSD); children with DSD; testis function; puberty; bone health; hormonal substitutive therapy
Special Issues and Collections in MDPI journals
Interests: basic and clinical aspects of the gonadal axis during pre- and postnatal development
Puberty is a complex physiological process, driving the passage from childhood to adulthood. It is characterized by the development of secondary sexual characteristics, increase in growth velocity, achievement of adult height, deep changes in neuropsychological development. The ultimate goal of this process is to reach full reproductive function, adult dimorphic physical features and maturity of thought.
Puberty depends on the interrelated role of “in utero” developmental programming, genetic factors, endocrine function and environmental issues (including nutrition and health status). Several pubertal disorders are due to genetic variants acting in the hypothalamus, pituitary and gonads. Abnormal pubertal development (both precocious or delayed puberty) can cause significant distress to the patient, and in some instances, may be a sign of life-threatening pathology or may deeply affect long-term quality of life. Health care providers require knowledge of the normal onset of timing and rate of progression of puberty, and they must be able to—at least—identify patients with abnormal pubertal development to be sent to appropriate specialist care.
The aim of the present Special Issue is to provide an overview of some issues related to minipuberty, physiology of puberty, the etiology and early recognition of delayed and precocious pubertal disorders. Current available treatments will be also addressed. Thus, this Special Issue will be a quality and updated resource for both researchers and clinicians involved in the fields of reproduction, neurodevelopment, pediatric and adolescent endocrinology, as well as gynecology.
This Special Issue that will be covered include, but are not restricted to:
- The genetic control of the onset of puberty
- Epigenetic interferences on the onset of puberty
- The molecular basis of central programming of reproductive axis in early life: its role on puberty timing
- Environmental clues affecting puberty onset
- Gut hormones and puberty
- Endocrine disrupters and puberty
- Puberty and the brain
- The genetic and endocrine control of pubertal growth spurt: implications for management of endocrine pediatric diseases
- Puberty in nutritional disorders
- Puberty and chronic diseases
- Genetics of hypogonadotropic hypogonadism
- Genetics of hypergonadotropic hypogonadism
- Genetics of autonomous gonadal activation
- Genetics of central precocious puberty
- Antimullerian hormone in the diagnosis and follow-up of pubertal disorders
- The molecular basis of minipuberty: its relevance in diagnosis and treatment of pubertal disorders
- Growth hormone/IGF1 axis and puberty
- Molecular basis of GnRH analogs treatment in central precocious puberty
- Genomics and non-genomic action of sex steroid therapy in puberty disorders
- Treatment of central and peripheral hypogonadisms
- Treatment of central precocious puberty
Dr. Silvano Bertelloni
Prof. Dr. Marek Niedziela
Dr. Rodolfo Rey
Manuscript Submission Information
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