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Radiomics: Advanced Techniques in Oncologic Imaging

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biophysics".

Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 6669

Special Issue Editor


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Guest Editor
Department of Diagnostic and Interventional Radiology, University of Leipzig, Liebigstraße, 2004103 Leipzig, Saxony, Germany
Interests: MRI; CT; DWI; oncologic imaging; radiomics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, the role of imaging has rapidly evolved from sole detection and measurement of malignant lesions to prognostication, treatment prediction and prediction of histologic features of tumors.

This led to a novel field of imaging analysis: Radiomics, which can aid in all of different clinical aspects of oncologic imaging. Due to the advent of artificial intelligence in imaging research and even in clinical routine, the field of oncologic imaging will be significantly improved. The advent of hybrid imaging with PET-CT and PET-MRT helps to better characterize tumors in a morphological and functional way.

Possible associations between imaging and histopathology features are identified due to deeper understanding of tumors by imaging modalities and analyses methods.

There is no doubt that clinical translation of these novel techniques will be achieved soon.

In this Special Issue, we aim to highlight recent advances in the context of Radiomics to predict prognostic informations of tumors and to elucidate possible associations between imaging and histopathology. Papers investigating these novel aspects of oncologic imaging are welcomed in this Special Issue.

Dr. Hans-Jonas Meyer
Guest Editor

Manuscript Submission Information

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Keywords

  • Radiomics
  • histopathology
  • texture analysis
  • CT
  • MRI
  • PET

Published Papers (1 paper)

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Research

14 pages, 1431 KiB  
Article
Machine Learning-Based Radiomics Signatures for EGFR and KRAS Mutations Prediction in Non-Small-Cell Lung Cancer
by Nguyen Quoc Khanh Le, Quang Hien Kha, Van Hiep Nguyen, Yung-Chieh Chen, Sho-Jen Cheng and Cheng-Yu Chen
Int. J. Mol. Sci. 2021, 22(17), 9254; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22179254 - 26 Aug 2021
Cited by 75 | Viewed by 5943
Abstract
Early identification of epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations is crucial for selecting a therapeutic strategy for patients with non-small-cell lung cancer (NSCLC). We proposed a machine learning-based model for feature selection and prediction of [...] Read more.
Early identification of epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations is crucial for selecting a therapeutic strategy for patients with non-small-cell lung cancer (NSCLC). We proposed a machine learning-based model for feature selection and prediction of EGFR and KRAS mutations in patients with NSCLC by including the least number of the most semantic radiomics features. We included a cohort of 161 patients from 211 patients with NSCLC from The Cancer Imaging Archive (TCIA) and analyzed 161 low-dose computed tomography (LDCT) images for detecting EGFR and KRAS mutations. A total of 851 radiomics features, which were classified into 9 categories, were obtained through manual segmentation and radiomics feature extraction from LDCT. We evaluated our models using a validation set consisting of 18 patients derived from the same TCIA dataset. The results showed that the genetic algorithm plus XGBoost classifier exhibited the most favorable performance, with an accuracy of 0.836 and 0.86 for detecting EGFR and KRAS mutations, respectively. We demonstrated that a noninvasive machine learning-based model including the least number of the most semantic radiomics signatures could robustly predict EGFR and KRAS mutations in patients with NSCLC. Full article
(This article belongs to the Special Issue Radiomics: Advanced Techniques in Oncologic Imaging)
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