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Redox Modulation by Antioxidants, Seen through the Energy Perspective

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 3067

Special Issue Editors


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Guest Editor
Department of Pharmacology and Toxicology, Faculty of Health, Medicine and Health Sciences, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands
Interests: molecular biology; cell biology; biochemistry; analytical chemistry; pharmacy; medical chemistry; clinical pharmacology; toxicology; reactive oxygen species; free radicals; antioxidants; oxidative stress; redox modulation; nutrition; flavonoids; thiols; glutathione; reactive intermediates; lipid peroxidation; kinetics; structure activity relationship; biomarkers
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E-Mail Website
Guest Editor
Department of Pharmacology and Toxicology, Maastricht University, 6200 MD Maastricht, The Netherlands
Interests: redox modulation; antioxidants; flavonoids; synthesis of antioxidants; quantum molecular calculations; structure activity relationship
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Co-Guest Editor
Department of Pharmacology and Toxicology, Faculty of Health, Medicine and Health Sciences, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands
Interests: redox modulation; antioxidants; flavonoids; structure activity relationship; free radicals; reactive oxygen species; traditional Chinese medicine
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Co-Guest Editor
Department of Pharmacology and Toxicology, Faculty of Health, Medicine and Health Sciences, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands
Interests: redox modulation; antioxidants; flavonoids; synthesis of antioxidants; quantum molecular calculations; structure activity relationship

Special Issue Information

Dear Colleagues,

Redox energy is essential for life, as it fuels all our biochemical processes. Most of the redox energy is safely channeled in the biochemical networks, but for some unknown reason, part of the oxidizing energy flow is uncontrolled. This deranged energy can, seemingly quite random, damage our cells. Intriguingly, the deranged energy also has a good side, e.g. it also triggers the healing process. The paradigm is that antioxidants can modulate the energy in such a way that the damage is mitigated, whereas the healing process is promoted.

This special issue is dedicated to further understanding the molecular mechanism of the redox modulation by antioxidants, seen through the energy perspective. We will consider manuscripts that provide insights on (i) how the energy is picked up by antioxidants, (ii) how the energy is modulated by flowing through the antioxidant molecule, (iii) how the modulated energy is taken up by the antioxidant network, and (iv) how the modulated energy can turn on redox master switches.

Prof. Dr. Guido R.M.M. Haenen
Dr. Mohamed Moalin
Dr. Ming Zhang
Dr. Zhengwen Li
Guest Editors

Manuscript Submission Information

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Keywords

  • redox modulation
  • antioxidant
  • redox master switch
  • molecular mechanism
  • redox energy
  • oxidative stress

Published Papers (1 paper)

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Review

17 pages, 3582 KiB  
Review
Flavonoids Seen through the Energy Perspective
by Zhengwen Li, Ming Zhang, Guido R. M. M. Haenen, Lily Vervoort and Mohamed Moalin
Int. J. Mol. Sci. 2022, 23(1), 187; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23010187 - 24 Dec 2021
Cited by 4 | Viewed by 2497
Abstract
In all life forms, opposing forces provide the energy that flows through networks in an organism, which fuels life. In this concept, health is the ability of an organism to maintain the balance between these opposing forces, which creates resilience, and a deranged [...] Read more.
In all life forms, opposing forces provide the energy that flows through networks in an organism, which fuels life. In this concept, health is the ability of an organism to maintain the balance between these opposing forces, which creates resilience, and a deranged flow of energy is the basis for diseases. Treatment should focus on adjusting the deranged flow of energy, e.g., by the redox modulating activity of antioxidants. A major group of antioxidants is formed by flavonoids, a group of polyphenolic compounds abundantly present in our diet. The objective here is to review how the redox modulation by flavonoids fits in the various concepts on the mode of action of bioactive compounds, so we can ‘see’ where there is overlap and where the missing links are. Based on this fundament, we should choose our research path aiming to ‘understand’ the redox modulating profile of specific flavonoids, so we can ultimately rationally apply the redox modulating power of flavonoids to improve our health. Full article
(This article belongs to the Special Issue Redox Modulation by Antioxidants, Seen through the Energy Perspective)
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