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Special Issue "Reproductive Immunology: Cellular and Molecular Biology 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 20 August 2021.

Special Issue Editors

Prof. Dr. Udo Jeschke
E-Mail Website
Guest Editor
University Hospital Augsburg, Interdisciplinary Center of Experimental Tumor Research, Stenglinstr. 2, 86156 Augsburg, Germany
Interests: ovarian cancer; breast cancer; cervical cancer; endometrial cancer, placenta
Special Issues and Collections in MDPI journals
Prof. Dr. Antonis Makrigiannakis
E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, Medical School, University of Crete, 71003 Heraklion, Greece
Interests: implantation; receptivity; endometrium; RIF; early pregnancy; trophoblast
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our previous Special Issue on “Reproductive Immunology: Cellular and Molecular Biology”.

Reproductive immunology in the 21st century still deals with a problem that has been known for decades—the fetus as semi-allograft and its response to the maternal immune system. Therefore, there is a strong need to solve problems such as spontaneous and recurrent miscarriages and, in addition, repeated implantation failure.
Furthermore, socioeconomical changes in an aging society are an additional challenge especially for the reproductive medicine specialist. Although highly developed in vitro fertilization techniques are available, many couples still face the problem of childlessness.
A quite new player in the field is the microbiome of the reproductive tract. For decades, it was believed that the uterus is sterile but an up to date analysis revealed that we not only have a vaginal microbiome but also a cervical, uterine, male, and even a placental microbiome.
Therefore, we would like to invite our colleagues to submit articles that deal with cellular and molecular mechanisms in the field of reproductive immunology to this Special Issue.

Prof. Dr. Udo Jeschke
Prof. Dr. Antonis Makrigiannakis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Spontaneous and recurrent miscarriage
  • Repeated implantation failure
  • Maternal immune cells
  • Microbiome
  • Assisted reproduction

Related Special Issue

Published Papers (2 papers)

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Review

Review
Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Trophoblast Functions
Int. J. Mol. Sci. 2021, 22(1), 433; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22010433 - 04 Jan 2021
Cited by 1 | Viewed by 788
Abstract
Peroxisome proliferator-activated receptors (PPARα, PPARβ/δ, and PPARγ) belong to the transcription factor family, and they are highly expressed in all types of trophoblast during pregnancy. The present review discusses currently published papers that are related to the regulation of [...] Read more.
Peroxisome proliferator-activated receptors (PPARα, PPARβ/δ, and PPARγ) belong to the transcription factor family, and they are highly expressed in all types of trophoblast during pregnancy. The present review discusses currently published papers that are related to the regulation of PPARs via lipid metabolism, glucose metabolism, and amino acid metabolism to affect trophoblast physiological conditions, including differentiation, maturation, secretion, fusion, proliferation, migration, and invasion. Recent pieces of evidence have proven that the dysfunctions of PPARs in trophoblast lead to several related pregnancy diseases such as recurrent miscarriage, preeclampsia, intrauterine growth restriction, and gestational diabetes mellitus. Moreover, the underlying mechanisms of PPARs in the control of these processes have been discussed as well. Finally, this review’s purposes are to provide more knowledge about the role of PPARs in normal and disturbed pregnancy with trophoblast, so as to find PPAR ligands as a potential therapeutic target in the treatment and prevention of adverse pregnancy outcomes. Full article
(This article belongs to the Special Issue Reproductive Immunology: Cellular and Molecular Biology 2.0)
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Review
Early Life Oxidative Stress and Long-Lasting Cardiovascular Effects on Offspring Conceived by Assisted Reproductive Technologies: A Review
Int. J. Mol. Sci. 2020, 21(15), 5175; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21155175 - 22 Jul 2020
Cited by 1 | Viewed by 900
Abstract
Assisted reproductive technology (ART) has rapidly developed and is now widely practised worldwide. Both the characteristics of ART (handling gametes/embryos in vitro) and the infertility backgrounds of ART parents (such as infertility diseases and unfavourable lifestyles or diets) could cause increased oxidative stress [...] Read more.
Assisted reproductive technology (ART) has rapidly developed and is now widely practised worldwide. Both the characteristics of ART (handling gametes/embryos in vitro) and the infertility backgrounds of ART parents (such as infertility diseases and unfavourable lifestyles or diets) could cause increased oxidative stress (OS) that may exert adverse influences on gametogenesis, fertilisation, and foetation, even causing a long-lasting influence on the offspring. For these reasons, the safety of ART needs to be closely examined. In this review, from an ART safety standpoint, the origins of OS are reviewed, and the long-lasting cardiovascular effects and potential mechanisms of OS on the offspring are discussed. Full article
(This article belongs to the Special Issue Reproductive Immunology: Cellular and Molecular Biology 2.0)
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