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The Research about Microbiome and Cancer
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The Research about Microbiome and Cancer

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 5368

Special Issue Editor

Prof. Maria Gazouli

E-Mail Website
Guest Editor
Department of Biology, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece
Interests: genetics; molecular biology; proteomics; microbiome; cancer; inflammation; nanomedicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

I recently accepted an invitation to serve as the Guest Editor for a Special Issue of the International Journal of Molecular Sciences on the subject of “Microbiome and Cancer”. As is well known, the microbiome is receiving considerable attention given its implication in a host of human diseases, including cancer. Its role in response to cancer treatment is becoming more and more apparent, with evidence suggesting that modulating the gut microbiome may impact responses to a number of cancer therapies.

Based on your expertise in this field, we would like to invite you to contribute with a review or full research paper for peer-review and possible publication in this Special Issue.

It is indexed by PubMed and SCIE. Its *Impact Factor* is  4.556 (2019)

International Journal of Molecular Sciences

https://0-www-mdpi-com.brum.beds.ac.uk/journal/ijms

Guest Editor

Maria Gazouli

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer
  • microbiome
  • microbiota

Published Papers (1 paper)

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Review

17 pages, 345 KiB  
Review
Gut Microbiota in Lung Cancer: Where Do We Stand?
by Konstantinos Georgiou, Blagoi Marinov, Ammad Ahmad Farooqi and Maria Gazouli
Int. J. Mol. Sci. 2021, 22(19), 10429; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms221910429 - 27 Sep 2021
Cited by 26 | Viewed by 4756
Abstract
The gut microbiota (GM) is considered to constitute a powerful “organ” capable of influencing the majority of the metabolic, nutritional, physiological, and immunological processes of the human body. To date, five microbial-mediated mechanisms have been revealed that either endorse or inhibit tumorigenesis. Although [...] Read more.
The gut microbiota (GM) is considered to constitute a powerful “organ” capable of influencing the majority of the metabolic, nutritional, physiological, and immunological processes of the human body. To date, five microbial-mediated mechanisms have been revealed that either endorse or inhibit tumorigenesis. Although the gastrointestinal and respiratory tracts are distant physically, they have common embryonic origin and similarity in structure. The lung microbiota is far less understood, and it is suggested that the crosslink between the human microbiome and lung cancer is a complex, multifactorial relationship. Several pathways linking their respective microbiota have reinforced the existence of a gut–lung axis (GLA). Regarding implications of specific GM in lung cancer therapy, a few studies showed that the GM considerably affects immune checkpoint inhibitor (ICI) therapy by altering the differentiation of regulatory T cells and thus resulting in changes in immunomodulation mechanisms, as discovered by assessing drug metabolism directly and by assessing the host immune modulation response. Additionally, the GM may increase the efficacy of chemotherapeutic treatment in lung cancer. The mechanism underlying the role of the GLA in the pathogenesis and progression of lung cancer and its capability for diagnosis, manipulation, and treatment need to be further explored. Full article
(This article belongs to the Special Issue The Research about Microbiome and Cancer)
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