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Special Issue "The Role of Sphingolipids in Oxidative Stress"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 31 August 2021.

Special Issue Editor

Dr. Norishi Ueda
Guest Editor
Department of Pediatrics, Public Central Hospital of Matto Ishikawa, Ishikawa, Japan
Interests: apoptosis; Bcl-2 family proteins; cell death; cell signaling; ceramide; hepcidin; iron metabolism; mitochondria; oxidative stress; pediatric nephrology; reactive oxygen species; sphingolipids

Special Issue Information

Dear Colleagues,

Reactive oxygen species (ROS) derived from cellular oxidative metabolism are essential for normal cellular processes. However, excess production of ROS and/or reduced antioxidant defense system following diverse stimuli cause oxidative stress in various cells, tissues and organs. Sphingolipids, structural components of biological membranes, function as signaling molecules to regulate cellular function and cell fate in response to diverse stimuli including oxidative stress. Increasing evidence highlights a crosstalk between ROS-antioxidants and sphingolipid metabolism and signaling including the effect of ROS-antioxidants on a ceramide-sphingosine-1-phosphate rheostat which regulates mitochondrial function including Bcl-2 family proteins and downstream signaling pathways, leading to modulation of cellular function and cell fate in various types of oxidative stress-mediated disorders.
This Special Issue aims to provide new insights into the role of a crosstalk between ROS-antioxidants and sphingolipid metabolism and signaling as well as the molecular and cellular mechanisms used by sphingolipids in the regulation of physiological, pathophysiological and pathological processes during oxidative stress. Advances in the development of new drugs, therapeutic targets or strategies to modulate sphingolipid-regulating enzymes, receptors, mitochondrial function, sphingolipid-induced signaling pathways which contribute to the regulation of oxidative stress-mediated disorders are also welcome. We welcome your contribution in the form of original research articles, reviews or expert opinions on all aspects of the role of sphingolipids in the regulation of oxidative stress.

Dr. Norishi Ueda
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • antioxidants
  • cell death (apoptosis, autophagy, necrosis)
  • Bcl-2 family proteins
  • cell proliferation/fibrosis/inflammation
  • ceramide
  • mitochondria
  • oxidative stress
  • reactive oxygen species
  • sphingolipid metabolism/signaling
  • sphingosine-1-phosphate

Published Papers

This special issue is now open for submission.
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