Dear Colleagues,

Tumors affecting the spine are a challenging pathologic entity that requires the collaboration of multiple medical specialties. The life expectancy of patients affected by tumors of the spine (primary or metastatic) has increased considerably. This is principally due to advances in the field of oncologic therapies and surgical solutions.

Molecular targeted therapy is changing the way we treat cancer. Knowing the molecular signature of a specific tumor can lead to targeted therapy and improved outcomes.

In parallel, the use of spinal surgery has increased considerably worldwide over the last 30 years, leading to the development of new, often minimally invasive, surgical approaches and techniques. Tremendous advances have been made in the field of biomaterials, for example, new carbon fiber implants, 3D-printed prosthesis, or “vertebral transplant” for reconstruction after the resection of tumors from the spine.

This Special Issue will accept articles on molecular research and molecular mechanisms concerning the pathophysiology of spine tumors, molecular and biological therapies, new surgical techniques, particle therapy, radiation therapy, radiation oncology, new materials, nanoparticles, and interventional radiology. Both basic science and clinical investigation articles are welcome. The issue aims to put together the advances reached in a field which is as multidisciplinary as spine oncology.

Dr. Alessandro Gasbarrini
Dr. Gisberto Evangelisti
Guest Editors

Manuscript Submission Information

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• Spine oncology
• Tumors of the spine
• Primary tumors
• Metastatic tumors
• Molecular signature
• Molecular and biological therapy
• Immunotherapy
• Spondilectomy
• En bloc resection
• Particle therapy
• Radiation oncology