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Scavenger Receptors in Inflammation

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 6755

Special Issue Editors

Instituto de Biologia Molecular e Celular, Porto, Portugal
Interests: T cell activation; inhibitory receptors; scavenger receptors; inflammation; alternative splicing
Instituto de Biologia Molecular e Celular, Porto, Portugal
Interests: scavenger receptors; inflammation; infection

Special Issue Information

Dear Colleagues,

Scavenger receptors are a diverse group of extracellular or membrane-bound receptors present in all metazoans, with individual members displaying varied roles in, cell differentiation, homeostasis, metabolism, apoptosis, and pathogen recognition, among many others. Given their broad interaction spectra, no unifying role has been ascribed to the ensemble of these receptors. However, many of them seem to participate in the control of the inflammatory response of the organism in response to injuries, infections, and other internal or external challenges. A major controversy arising from the recent advances in the field and published data is whether scavenger receptors promote inflammation or, on the contrary, their role is mostly anti-inflammatory. In this Special Issue, we will focus on the roles of different scavenger receptors of diverse genetic families in inflammation to finally clarify whether or not they share similar or related roles, or whether their functions may vary and be dependent on the biological context.

Dr. Alexandre M. Carmo
Dr. Liliana Oliveira
Guest Editors

Manuscript Submission Information

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Keywords

  • scavenger receptors
  • inflammation
  • receptors
  • immunity
  • pattern recognition receptors
  • endocytosis
  • pathogen clearance
  • lipid transport
  • disorders
  • autoimmunity
  • chronic diseases
  • immunological adaptive responses
  • defense mechanisms
  • immune homeostasis
  • sepsis
  • cytokine storms

Published Papers (2 papers)

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Review

14 pages, 1431 KiB  
Review
Contribution of Evolutionary Selected Immune Gene Polymorphism to Immune-Related Disorders: The Case of Lymphocyte Scavenger Receptors CD5 and CD6
by Sergi Casadó-Llombart, María Velasco-de Andrés, Cristina Català, Alejandra Leyton-Pereira, Francisco Lozano and Elena Bosch
Int. J. Mol. Sci. 2021, 22(10), 5315; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105315 - 18 May 2021
Cited by 4 | Viewed by 2561
Abstract
Pathogens are one of the main selective pressures that ancestral humans had to adapt to. Components of the immune response system have been preferential targets of natural selection in response to such pathogen-driven pressure. In turn, there is compelling evidence showing that positively [...] Read more.
Pathogens are one of the main selective pressures that ancestral humans had to adapt to. Components of the immune response system have been preferential targets of natural selection in response to such pathogen-driven pressure. In turn, there is compelling evidence showing that positively selected immune gene variants conferring increased resistance to past or present infectious agents are today associated with increased risk for autoimmune or inflammatory disorders but decreased risk of cancer, the other side of the same coin. CD5 and CD6 are lymphocytic scavenger receptors at the interphase of the innate and adaptive immune responses since they are involved in both: (i) microbial-associated pattern recognition; and (ii) modulation of intracellular signals mediated by the clonotypic antigen-specific receptor present in T and B cells (TCR and BCR, respectively). Here, we review available information on CD5 and CD6 as targets of natural selection as well as on the role of CD5 and CD6 variation in autoimmunity and cancer. Full article
(This article belongs to the Special Issue Scavenger Receptors in Inflammation)
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14 pages, 1346 KiB  
Review
Multifaceted Roles of CD5L in Infectious and Sterile Inflammation
by Lidia Sanchez-Moral, Neus Ràfols, Clara Martori, Tony Paul, Érica Téllez and Maria-Rosa Sarrias
Int. J. Mol. Sci. 2021, 22(8), 4076; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22084076 - 15 Apr 2021
Cited by 18 | Viewed by 3778
Abstract
CD5L, a protein expressed and secreted mainly by macrophages, is emerging as a critical immune effector. In addition to its well-defined function as an anti-apoptotic protein, research over the last decade has uncovered additional roles that range from pattern recognition to autophagy, cell [...] Read more.
CD5L, a protein expressed and secreted mainly by macrophages, is emerging as a critical immune effector. In addition to its well-defined function as an anti-apoptotic protein, research over the last decade has uncovered additional roles that range from pattern recognition to autophagy, cell polarization, and the regulation of lipid metabolism. By modulating all these processes, CD5L plays a key role in highly prevalent diseases that develop by either acute or chronic inflammation, including several infectious, metabolic, and autoimmune conditions. In this review, we summarize the current knowledge of CD5L and focus on the relevance of this protein during infection- and sterile-driven inflammatory pathogenesis, highlighting its divergent roles in the modulation of inflammation. Full article
(This article belongs to the Special Issue Scavenger Receptors in Inflammation)
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