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Special Issue "Scavenger Receptors in Inflammation"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (30 April 2021).

Special Issue Editors

Dr. Alexandre M. Carmo
E-Mail Website
Guest Editor
Instituto de Biologia Molecular e Celular, Porto, Portugal
Interests: T cell activation; inhibitory receptors; scavenger receptors; inflammation; alternative splicing
Dr. Liliana Oliveira
E-Mail Website
Guest Editor
Instituto de Biologia Molecular e Celular, Porto, Portugal
Interests: scavenger receptors; inflammation; infection

Special Issue Information

Dear Colleagues,

Scavenger receptors are a diverse group of extracellular or membrane-bound receptors present in all metazoans, with individual members displaying varied roles in, cell differentiation, homeostasis, metabolism, apoptosis, and pathogen recognition, among many others. Given their broad interaction spectra, no unifying role has been ascribed to the ensemble of these receptors. However, many of them seem to participate in the control of the inflammatory response of the organism in response to injuries, infections, and other internal or external challenges. A major controversy arising from the recent advances in the field and published data is whether scavenger receptors promote inflammation or, on the contrary, their role is mostly anti-inflammatory. In this Special Issue, we will focus on the roles of different scavenger receptors of diverse genetic families in inflammation to finally clarify whether or not they share similar or related roles, or whether their functions may vary and be dependent on the biological context.

Dr. Alexandre M. Carmo
Dr. Liliana Oliveira
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • scavenger receptors
  • inflammation
  • receptors
  • immunity
  • pattern recognition receptors
  • endocytosis
  • pathogen clearance
  • lipid transport
  • disorders
  • autoimmunity
  • chronic diseases
  • immunological adaptive responses
  • defense mechanisms
  • immune homeostasis
  • sepsis
  • cytokine storms

Published Papers (1 paper)

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Review

Open AccessReview
Multifaceted Roles of CD5L in Infectious and Sterile Inflammation
Int. J. Mol. Sci. 2021, 22(8), 4076; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22084076 - 15 Apr 2021
Viewed by 286
Abstract
CD5L, a protein expressed and secreted mainly by macrophages, is emerging as a critical immune effector. In addition to its well-defined function as an anti-apoptotic protein, research over the last decade has uncovered additional roles that range from pattern recognition to autophagy, cell [...] Read more.
CD5L, a protein expressed and secreted mainly by macrophages, is emerging as a critical immune effector. In addition to its well-defined function as an anti-apoptotic protein, research over the last decade has uncovered additional roles that range from pattern recognition to autophagy, cell polarization, and the regulation of lipid metabolism. By modulating all these processes, CD5L plays a key role in highly prevalent diseases that develop by either acute or chronic inflammation, including several infectious, metabolic, and autoimmune conditions. In this review, we summarize the current knowledge of CD5L and focus on the relevance of this protein during infection- and sterile-driven inflammatory pathogenesis, highlighting its divergent roles in the modulation of inflammation. Full article
(This article belongs to the Special Issue Scavenger Receptors in Inflammation)
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