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Special Issue "Stem Cell Activation in Adult Organism 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 15 July 2021.

Special Issue Editors

Prof. Dr. Daniela Salvatori
E-Mail Website
Guest Editor
Department of Clinical Sciences, Anatomy and Physiology, Faculty of Veterinary Medicine, Utrecht University, 3584 Utrecht, The Netherlands
Interests: pluripotent stem cells; cardiology; mouse models; gene therapy; nuclear reprogramming
Prof. Dr. Wilhelm Bloch
E-Mail Website
Guest Editor
Institute of Cardiology and Sports Medicine, Department of Molecular and Cellular Sport Medicine, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933 Cologne, Germany
Interests: exercise biology; stem and progenitor mediated tissue adaptation; epigenetics and sport; mechanism of physical training in oncology; muscle growth and repair; vascular biology
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is the continuation of our 2015 Special Issue, “Stem Cell Activation in Adult Organism” https://0-www-mdpi-com.brum.beds.ac.uk/journal/ijms/special_issues/stem_cell_active.

The research on stem cells has developed as a promising area of biology in the last few decades. Meanwhile, the potential of stem cell-based tissue regeneration in the adult organism is recognized for nearly all organs and tissues, such as muscle, heart, brain, lung, mesenchymal, epithelial, and connective tissues. At the beginning of stem cell research for regeneration and repair in adults, a strong focus was given to embryonic stem cells, followed by a search for adult stem cell populations, which can be used, by virtue of their high differentiation potential, to replace organ and tissue specific cell types. In the last few years, it has been recognized that the stem cell potential of terminal, differentiated cells can be rescued by reprogramming. While first strategies are orientated for the ex vivo reprogramming of terminal differentiated cells into multipotent stem cells, increasing knowledge about the reprogramming mechanisms and the influencing factors supporting mobilization of tissue stem cells or the reprogramming of tissue specific cells to stem and progenitor cells, allows us to currently and additionally develop strategies for the endogenous mobilization of stem cells and the reprogramming of differentiated cells from different tissues. Local and systemic factors, such as cytokines, the extracellular matrix, and supporting cells are crucial for understanding of mobilization strategies. These strategies can be used for systemic and local stem cell-based therapy.

This Special Issue, “Stem Cell Activation in Adult Organism 2.0,” will cover a selection of recent research topics and current review articles in the field of stem cell research for the regeneration and repair of different tissues and organs in the adult organism. Experimental papers, up-to-date review articles, and commentaries are all welcome.

Prof. Dr. Daniela Salvatori
Prof. Dr. Wilhelm Bloch
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • adult stem cell
  • reprogramming
  • stem cell therapy
  • signaling and mechanism
  • growth factors
  • extra cellular matrix
  • homing
  • transdifferentiation

Published Papers

This special issue is now open for submission.
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