Dear Colleagues,

Epigenetic regulation in the cells can direct transcriptional programs to direct the identity, cell fate, and functions of various cell types in the body despite having the same genome sequence. Several aspects of epigenetic regulatory proccesses include base-modification of DNA and RNA, post-translational modifications of histones and their variants, changing the compaction and looping of chromatin, and the expression of long and short non-coding RNAs.

Modifications of biomolecules, such as DNA, chromatin, and RNA regulate various cellular processes, including the recruitment and binding of transcription factors and machinery, chromatin organization, as well as the degree and timing of transcriptional activation and repression.

Epigenetic processes are shown to be important for stem cell self-renewal, proliferation, cell-fate commitment, and differntiation during embryonic development. When these processes are disrupted, diseases such as cancer may originate, progress, relapse post-therapy or develop drug resistance.

Dr. Manching Ku
Guest Editor

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• Epigenetics
• Epitranscriptomics/RNA modifications
• Histone variants
• Histone modifications
• DNA methylation
• Non-coding RNA
• Long-range chromatin interaction
• Phase separation
• Epigenetic modification