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Special Issue "Stochastics in Epigenetics"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Informatics".

Deadline for manuscript submissions: closed (30 September 2021).

Special Issue Editors

Dr. Michelle Lacey
E-Mail Website
Guest Editor
Department of Mathematics and Department of Biostatistics and Data Science, Tulane University, New Orleans, LA 70112, USA
Interests: statistics; multivariate modeling; epigenetics; data integration; bioinformatics; methylation; genomics
Prof. Dr. Melanie Ehrlich
E-Mail Website
Guest Editor
Hayward Human Genetics Center, Tulane Cancer Center, and the Center for Bioinformatics and Genomics, Tulane University Health Sciences Center, New Orleans, LA, USA
Interests: DNA methylation; chromatin epigenetics; regulation of skeletal muscle development; cancer epigenetics
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Superimposed on orderly, genetically programmed epigenetic changes associated with differentiation and certain physiological states are well-documented stochastic changes in epigenetics at the level of individual chromosomes. Models have been proposed to characterize sources of random variation not only in DNA methylation, but also in histone modifications and other aspects of chromatin epigenetics. For example, the accumulation of stochastic epigenetic mutations (SEM) involving DNA methylation change is a marker of chronological aging and is also associated with various other conditions, including cancer and preterm birth. The influence of both intra- and inter-organismal stochastic variation is often overlooked in the analysis and interpretation of epigenetic data and studies of transcription and phenotypic change.

The purpose of the issue “Stochastics in Epigenetics” is to provide an integrated view of the challenges presented by stochastic variation for epigenetic research, to highlight recent developments from both experimental and analytical perspectives and to provide insights into the biological consequences of SEM.    

Dr. Michelle Lacey
Prof. Dr. Melanie Ehrlich
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • epigenetics
  • DNA methylation
  • histone modification
  • stochastic process
  • phenotype switching
  • methylation heterogeneity
  • epigenetic polymorphism
  • entropy
  • stochastic epigenetic mutations

Published Papers

There is no accepted submissions to this special issue at this moment.
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