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Special Issue "Stress-Related Disorders and Depression: From Molecular Basis to Therapy"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editors

Prof. Dr. Irena Nalepa
E-Mail Website
Guest Editor
Department of Brain Biochemistry, Maj Institute of Pharmacology of the Polish Academy of Sciences, Smętna 12, 31-343 Krakow, Poland
Interests: neuroscience; neuropharmacology; stress-related disorders; depression; psychotropic drugs; GPCR signaling; noradrenergic system; neuroplasticity
Special Issues, Collections and Topics in MDPI journals
Dr. Agnieszka Zelek-Molik
E-Mail Website
Co-Guest Editor
Department of Brain Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343 Kraków, Poland
Interests: drug addiction; G-protein-coupled receptors; glutamate; noradrenaline; signaling proteins; stress

Special Issue Information

Dear Colleagues,

Stress is defined as a challenge to the homeostasis of an organism by events coming from the environment. Two major systems are essential in the response to stressors: the sympathetic adrenomedullary system and the hypothalamic–pituitary–adrenal axis (HPA). Elevated by stress, noradrenaline and HPA-axis-related hormones (including CRH, vasopressin, ACTH, corticosteroids) influence the gene transcription processes and the function of neurotransmitter systems. The immune system responsiveness is also affected. Through altering brain structure, chemistry, and function, chronic stress contributes to depression and various anxiety disorders, including posttraumatic stress disorder (PTSD). There is evidence demonstrating that chronic stress may also contribute to addiction and obesity.

The purpose of this Special Issue is to collect original research articles and review papers that concern the study of how the brain transduces environmental stress exposure into depression and stress-related diseases. We aim to bring together the most recent studies that use different experimental approaches in vivo or in vitro relating to:

  1. molecular and cellular responses to stress;
  2. stress-induced changes in the neurochemical cross-talk between signaling systems in the brain;
  3. methods to study the effects of various stressors in psychiatric disease models;
  4. stress vulnerability and resilience;
  5. stress biomarkers;
  6. therapies for stress-related disorders.

Prof. Dr. Irena Nalepa
Guest Editor

Dr. Agnieszka Zelek-Molik
co-Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • psychobiology of stress
  • depression
  • posttraumatic stress disorder
  • anxiety disorders
  • animal models
  • biogenic monoamines
  • glucocorticoids
  • inflammation
  • antidepressant and anxiolytic drugs

Published Papers

This special issue is now open for submission.
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