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Special Issue "Diverse Models of Stress 2.0: From Animal Model to Human and Back"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editors

Prof. Dr. Gil Atzmon
E-Mail Website
Guest Editor
Epigenetics and Genomics of Aging/Longevity, Department of Biology, Faculty of Natural Sciences University of Haifa Mount Carmel, Haifa 31905, Israel
Interests: longevity; genomic; epigenomic; genetic; epigenetic; healthy aging; healthy lifespan; diabetes
Special Issues and Collections in MDPI journals
Dr. Ziv Ardi
Guest Editor
Department of Behavioral Sciences, Kinneret Academic College, Sea of Galilee, Israel
Interests: neurobiology of stress-related disorders; risk and resilience factors; synaptic plasticity; hippocampal GABAergic transmission

Special Issue Information

Dear Colleagues,

During the day to day living, an organism is exposed to various stressors which place their mark on its molecular systems. Some effects of these stressors might last for moments and some for decades. The challenge is to reveal these effects, understand the mechanism and their collateral outcomes, and treat them. For example, a great amount of evidence shows that exposure to stress can cause long-lasting epigenetic changes that lead to alterations of gene expression and affect the whole organism. The best model to steady this course of action is human. However, when it comes to exploring the type of mechanisms and introducing stressors, design, genetic, and environmental manipulation limits the use of the human model and necessitates the development of animal models. Once the whole path of a giving subjects is uncovered, the test in humans becomes more approachable.

In this Special Issue, we aim to capture state-of-the-art, innovative, and up-to-date studies that are in accordance with this line of thought either using humans to tackle the stress condition and its effects or other organisms to study mechanisms and translate to human treatment.

Prof. Dr. Gil Atzmon
Dr. Ziv Ardi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Stress
  • Animal model
  • Epigenetic
  • Genetics

Published Papers

This special issue is now open for submission.
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