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Special Issue "Stress Response Effectors and Strategies in Probiotics"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 28 February 2022.

Special Issue Editor

Dr. Daniela Fiocco
E-Mail Website
Guest Editor
Department of Clinical and Experimental Medicine, University of Foggia, Via Napoli, 20, 71122 Foggia, Italy
Interests: probiotics; lactic acid bacteria; host-probiotic interactions; prebiotics; stress response; small heat shock proteins; melanogenesis; antimicrobial activity
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Probiotics are gaining increasing attention thanks to the health-promoting activities associated to their dietary intake, and to their occurrence and persistence in the gut microbiota. The use of probiotics, including their production, storage, commercialization, and ingestion in the form of food or supplements, expose these microbes to a vast array of environmental stresses, which may affect their physiology and decrease their viability, hence impairing their beneficial effects on the host. Studies conducted so far, mostly in model probiotic species (i.e., lactobacilli and bifidobacteria), have evidenced complex pathways and multiple molecular strategies that are elicited to endure even harsh conditions, indicating a high adaptability. According to the specific type of stress, probiotic cells have been found to respond by i) up-regulating chaperones that stabilize, refold, and/or prevent precipitation of denaturing proteins; ii) producing proteolytic enzymes to degrade irreversibly damaged structures; iii) activating diverse detoxifying systems; and iv) modulating cell membrane lipid composition and surface adhesion properties.

Insight into the molecular mechanisms carried out by probiotics to cope with stress shall increase our overall knowledge of the cellular strategies to overcome stress, thereby providing a paradigm for general cell stress response. Moreover, from a more applicative point of view, such studies may help to rationalize the use of beneficial microbes and to improve their efficacy—for example, by providing the scientific basis for implementing technological handling and delivery systems, for finding molecular markers allowing the selection of robust strains, or even for modulating some aspects of our own lifestyle in order to maximize the performance of the probiotics hosted in our gut.

This Special Issue aims to collect original research articles and reviews covering recent advances related to the stress response mechanisms in probiotics.

Dr. Daniela Fiocco
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • probiotic
  • lactobacilli
  • bifidobacteria
  • environmental stress
  • acidity
  • heat stress
  • bile stress
  • ROS
  • chaperones
  • protein denaturation
  • membrane lipid composition
  • detoxifying enzymes/pumps
  • heat shock proteins
  • induced thermotolerance
  • cross-protection
  • prebiotic

Published Papers

This special issue is now open for submission.
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