Special Issue "Molecular Mechanisms Underlying Stress Response and Resilience"
Deadline for manuscript submissions: 31 August 2021.
Interests: CRF; ACTH; Cushing's disease
Interests: orchestration in stress response focused on the HPA-axis; inharmonious in post-growth stress response due to fetal malnutrition based on the DOHaD theory
A variety of stressors induce various physiological responses by stimulating sympathetic, neuroendocrine, and behavioral systems. While stress activates the hypothalamic-pituitary-adrenal (HPA) axis, it suppresses the hypothalamic-pituitary-gonadal axis. Stress also modulates the immune system. Corticotropin-releasing factor (CRF) in the hypothalamus plays a central role in regulating the stress response. CRF stimulates the release of adrenocorticotropic hormone (ACTH) from the anterior pituitary. ACTH stimulates the secretion of glucocorticoids from the adrenal glands. The activated HPA axis is suppressed by the negative feedback effect of glucocorticoids. Glucocorticoids are essential for stress coping, stress resilience, and homeostasis. The stressed state may be relieved or reduced by an action, medicine, or therapy. The molecular mechanisms underlying stress response and resilience, however, are not fully understood. This Special Issue is focused on stress response and resilience, and will include original research articles and reviews on aspects related to their molecular mechanisms.
Dr. Kazunori Kageyama
Dr. Takahiro Nemoto
Manuscript Submission Information
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