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Special Issue "Molecular Mechanisms Underlying Stress Response and Resilience"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 August 2021.

Special Issue Editors

Dr. Kazunori Kageyama
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Guest Editor
Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, Aomori, Japan
Interests: CRF; ACTH; Cushing's disease
Dr. Takahiro Nemoto
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Guest Editor
Department of Bioregulatory Science (Physiology), Nippon Medical School, Tokyo, Japan
Interests: orchestration in stress response focused on the HPA-axis; inharmonious in post-growth stress response due to fetal malnutrition based on the DOHaD theory

Special Issue Information

Dear Colleagues,

A variety of stressors induce various physiological responses by stimulating sympathetic, neuroendocrine, and behavioral systems. While stress activates the hypothalamic-pituitary-adrenal (HPA) axis, it suppresses the hypothalamic-pituitary-gonadal axis. Stress also modulates the immune system. Corticotropin-releasing factor (CRF) in the hypothalamus plays a central role in regulating the stress response. CRF stimulates the release of adrenocorticotropic hormone (ACTH) from the anterior pituitary. ACTH stimulates the secretion of glucocorticoids from the adrenal glands. The activated HPA axis is suppressed by the negative feedback effect of glucocorticoids. Glucocorticoids are essential for stress coping, stress resilience, and homeostasis. The stressed state may be relieved or reduced by an action, medicine, or therapy. The molecular mechanisms underlying stress response and resilience, however, are not fully understood. This Special Issue is focused on stress response and resilience, and will include original research articles and reviews on aspects related to their molecular mechanisms.

Dr. Kazunori Kageyama
Dr. Takahiro Nemoto
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stress
  • resilience
  • relaxant
  • hypothalamus
  • CRF
  • ACTH
  • glucocorticoid

Published Papers (1 paper)

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Research

Open AccessArticle
Orexin A Enhances Pro-Opiomelanocortin Transcription Regulated by BMP-4 in Mouse Corticotrope AtT20 Cells
Int. J. Mol. Sci. 2021, 22(9), 4553; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094553 - 27 Apr 2021
Viewed by 185
Abstract
Orexin is expressed mainly in the hypothalamus and is known to activate the hypothalamic–pituitary–adrenal (HPA) axis that is involved in various stress responses and its resilience. However, the effects of orexin on the endocrine function of pituitary corticotrope cells remain unclear. In this [...] Read more.
Orexin is expressed mainly in the hypothalamus and is known to activate the hypothalamic–pituitary–adrenal (HPA) axis that is involved in various stress responses and its resilience. However, the effects of orexin on the endocrine function of pituitary corticotrope cells remain unclear. In this study, we investigated the roles of orexin A in pro-opiomelanocortin (POMC) transcription using mouse corticotrope AtT20 cells, focusing on the bone morphogenetic protein (BMP) system expressed in the pituitary. Regarding the receptors for orexin, type 2 (OXR2) rather than type 1 (OX1R) receptor mRNA was predominantly expressed in AtT20 cells. It was found that orexin A treatment enhanced POMC expression, induced by corticotropin-releasing hormone (CRH) stimulation through upregulation of CRH receptor type-1 (CRHR1). Orexin A had no direct effect on the POMC transcription suppressed by BMP-4 treatment, whereas it suppressed Smad1/5/9 phosphorylation and Id-1 mRNA expression induced by BMP-4. It was further revealed that orexin A had no significant effect on the expression levels of type I and II BMP receptors but upregulated inhibitory Smad6/7 mRNA and protein levels in AtT20 cells. The results demonstrated that orexin A upregulated CRHR signaling and downregulated BMP-Smad signaling, leading to an enhancement of POMC transcription by corticotrope cells. Full article
(This article belongs to the Special Issue Molecular Mechanisms Underlying Stress Response and Resilience)
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