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Special Issue "The Stromal-Epithelial Dialogues in Health and Disease"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: closed (20 October 2021).

Special Issue Editor

Dr. Audrey Ferrand
E-Mail Website
Guest Editor
IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, 31024 Toulouse, France
Interests: interactions between the stromal environment; fibroblasts; extracellular matrix; intestinal epithelium; regulation of the stem cells; 3D organoid model

Special Issue Information

Dear Colleagues,

As you know, epithelial tissues are the main interfaces between our inner body and the external world. Their renewal and integrity are crucial in order to preserve our body from damage generated by harmful substances and exposures. These highly specialized tissues are involved in diverse functions such as microbe protection, nutrients and water absorption, hormones and enzymes secretion, gas exchanges, etc. In order to assure their maintenance and multiple roles, epithelia are supported by the stroma that corresponds to the connective tissue whose main functions, in regard to the epithelia and aside from immunity, are mechanical (support) and metabolic (nutrition and various exchanges). The stroma is composed of a cellular compartment including fibroblasts, immune cells, vessels, nerves, and glial cells, and an acellular one, the extracellular matrix. In homeostasis, actors of both stromal compartments are active players in the regulation of the renewal, differentiation, integrity, and functions of epithelial tissues. Moreover, it is now well established that under pathological conditions (inflammation, metabolic disorders, and cancer), alteration of either the epithelial or the stromal tissue will immediately affect the other one.

This Special Issue focuses on the latest advances in understanding the stromal–epithelial dialogue involved in physiological and/or pathological contexts. We will address how it participates to cell fates, tissue architecture and remodeling, during the different steps of development, under homeostasis or disease status, and the cellular and molecular events involved.

Dr. Audrey Ferrand
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • epithelial tissues
  • epithelia
  • stroma
  • connective tissue
  • immunity
  • metabolic

Published Papers

There is no accepted submissions to this special issue at this moment.
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