Special Issue "Advances in Kinase Drug Discovery"
Deadline for manuscript submissions: closed (30 September 2020).
Interests: myeloproliferative neoplasms; protein kinase structure; JAK2; MPL; structure-guided drug design; protein engineering
Interests: cell-cycle; structure activity relationship; fragment-based drug discovery; protein–protein interactions; cyclin-dependent kinases
We are delighted to announce a call for submissions to a special issue of the International Journal of Molecular Sciences on the topic of Advances in Kinase Drug Discovery. More than fifty protein kinase inhibitors had been approved for clinical use to 11 December 2019, including seven in 2019, and many more were under clinical investigation (PKI-DB, Carles, et al. (2018) Molecules 23, 908). Lipid, nucleotide and small molecule kinases represent equally interesting, if less often exploited therapeutic targets. Recent technological advances ranging from the application of biophysical techniques to ever larger and more complex systems to novel cellular target engagement assays, alongside a more nuanced understanding of resistance mechanisms have enabled exciting progress in this area of drug discovery.
We encourage submission of both original research articles and topical reviews on all aspects of drug discovery targeting the phosphotransferase enzyme family. All submitted articles will undergo peer review.
Dr. Julie Tucker
Dr. Mathew Martin
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- structure-guided drug discovery
- kinase inhibitor
- protein kinase
- lipid kinase
- nucleotide kinase
- sugar kinase
- fragment-based drug discovery
- allosteric inhibitor
- ATP-competitive inhibitor