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Special Issue "The Synaptic Vesicle Cycle as It Relates to Neurotransmitter Release at Nerve Terminals"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editor

Prof. Cameron Gundersen
E-Mail Website
Guest Editor
David Geffen School of Medicine at UCLA, Department of Molecular and Medical Pharmacology, Los Angeles, United States
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

It is widely acknowledged that the final steps underlying fast, synchronous exocytosis at nerve terminals involve a small cast of proteins: Synaptotagmin-1 (or, -2), the three SNARE (soluble, N-ethyl-maleimide sensitive factor attachment receptor) proteins, complexins, and muncs-13 and -18. However, in spite of significant contributions from imaging and structural biology, genetic structure–function analyses, and biochemical reconstitution experiments, the field has still not converged on a description of the final steps that lead to the fusion of the synaptic vesicle membrane with the presynaptic plasma membrane. This Special Issue will focus on investigations ranging from the control of Ca2+ entry at nerve terminals to detailed studies of the machinery that catalyzes the membrane fusion step of regulated exocytosis. In addition, this issue will address all of the subsequent steps in the synaptic vesicle cycle, including the recycling and re-loading of synaptic vesicles with a transmitter along with their transport to release sites.

Prof. Cameron Gundersen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • exocytosis
  • endocytosis
  • presynaptic Ca channels
  • neurotransmitter synthesis
  • vesicular neurotransmitter transporters
  • presynaptic Ca homeostasis
  • secretory mechanisms
  • SNAREs
  • synaptotagmin

Published Papers

This special issue is now open for submission.
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