Special Issue "The Synaptic Vesicle Cycle as It Relates to Neurotransmitter Release at Nerve Terminals"
Deadline for manuscript submissions: 31 October 2021.
Special Issues and Collections in MDPI journals
It is widely acknowledged that the final steps underlying fast, synchronous exocytosis at nerve terminals involve a small cast of proteins: Synaptotagmin-1 (or, -2), the three SNARE (soluble, N-ethyl-maleimide sensitive factor attachment receptor) proteins, complexins, and muncs-13 and -18. However, in spite of significant contributions from imaging and structural biology, genetic structure–function analyses, and biochemical reconstitution experiments, the field has still not converged on a description of the final steps that lead to the fusion of the synaptic vesicle membrane with the presynaptic plasma membrane. This Special Issue will focus on investigations ranging from the control of Ca2+ entry at nerve terminals to detailed studies of the machinery that catalyzes the membrane fusion step of regulated exocytosis. In addition, this issue will address all of the subsequent steps in the synaptic vesicle cycle, including the recycling and re-loading of synaptic vesicles with a transmitter along with their transport to release sites.
Prof. Cameron Gundersen
Manuscript Submission Information
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- presynaptic Ca channels
- neurotransmitter synthesis
- vesicular neurotransmitter transporters
- presynaptic Ca homeostasis
- secretory mechanisms