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Special Issue "Molecular Mechanisms of Synaptic Plasticity (3.0): Genetic and Environmental Factors Involved in Neuronal Changes"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 30 June 2021.

Special Issue Editor

Dr. Giuseppina Martella
E-Mail Website
Guest Editor
Laboratory of Neurophysiology and Plasticity, Fondazione Santa Lucia, and University of Rome Tor Vergata, Rome, Italy
Interests: pathophysiology; movement disorders; motor memory; motor dysfunction; synaptic plasticity; brain circuitry; basal ganglia; striatum (putamen); medium spiny neurons; mitochondria; neurologic and phychiatric disorders; protein synthesis
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Synaptic plasticity is a complex and crucial neuronal mechanism linked to principal memory and motor functions. During the developmental period into old age, the neural frame is subject to structural and functional modifications in response to external stimuli. This essential skill of neuronal cells underpins the ability to learn of mammalian organisms.

Synaptic plasticity phenomena include microscopic changes such as spine pruning and macroscopic changes such as cortical remapping in response to injury. The increase of neurological and neuropsychiatric disorders in the current century—although this increase did not occur among the aging population—has resulted in an improved urgency to understand the aberrant processes connected to these diseases.

Moreover, plasticity in the brain is affected by genetic impacts and responds to changes in the environment.Normally, during their life, neurons that develop stronger connections and those that are hardly or never used to die. The brain is able to adapt to the changing environment by developing new connections and pruning away weak ones. Genetic contribution to these structural changes is varied and can modulate physiological as well as pathological network.

In the last decades, it has been highlighted that de novo protein synthesis, (mRNA transcription mRNA and protein degradation, histone acetylation, DNA methylation, and miRNA regulation), as well as a new set of signaling molecules (endogenously generated cannabinoids, peptides, Neurotrophins, protein kinases, and ubiquitin-proteasome system), has been implicated in synaptic transmission and plasticity.

The aim of this Special Issue is to collect original papers, reviews, case reports, and other forms of scientific communication that could increase the interest of scientists in synaptic plasticity phenomena.

Dr. Giuseppina Martella
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • synaptic plasticity
  • synaptic mechanism
  • synaptic response
  • neural network
  • neurological and neuropsychiatric disorders
  • molecular pathway
  • neuronal circuitry
  • dynamic changes in synapses
  • neuron function re-arraignments
  • motor and memory learning

Published Papers

This special issue is now open for submission.
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