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Special Issue "Therapeutic Drugs Targeting DNA"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 15 September 2021.

Special Issue Editors

Prof. Dr. Mitsuko Masutani
E-Mail Website
Guest Editor
Department of Molecular and Genomic Biomedicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan
Center for Bioinformatics and Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan
Interests: DNA repair/DNA damage response; molecular targeted therapy; poly ADP-ribosylation; chromatin regulation; radiation oncology
Special Issues and Collections in MDPI journals
Dr. Tadayoshi Bessho
E-Mail Website
Guest Editor
The Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198-6805, USA
Interests: DNA repair/DNA damage response; nucleotide excision repair; double strand break repair; DNA interstrand cross-link repair; base excision repair

Special Issue Information

Dear Colleagues,

DNA-targeting drugs that directly interact with DNA, such as alkylating, crosslinking, and DNA intercalating agents have been used in cancer chemotherapies for decades with some success. Recently, drugs that selectively target DNA repair factors have been developed, with some of these drugs currently under clinical trial. DNA repair inhibitors with a selective target, such as inhibitors of poly(ADP-ribose) polymerase, indirectly introduce lethal DNA damage to cancer cells. Inhibitors of epigenetic and chromatin regulation also indirectly target DNA, causing cancer cell death. DNA targeting drugs that induce lethal DNA damage directly or indirectly will become a critical component of effective cancer chemotherapies in the future. Thus, this Special Issue will focus on the use of DNA targeting drugs, namely those that target DNA repair and epigenetic and chromatin regulation, for various diseases, including cancers. Authors are invited to submit original research articles and reviews on various types of molecular and biological aspects of DNA targeting drugs for inclusion in this Special Issue.

Prof. Dr. Mitsuko Masutani
Dr. Tadayoshi Bessho
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers

This special issue is now open for submission.
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