Special Issue "Therapeutic Drugs Targeting DNA"
Deadline for manuscript submissions: 30 June 2021.
Center for Bioinformatics and Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan
Interests: DNA repair/DNA damage response; molecular targeted therapy; poly ADP-ribosylation; chromatin regulation; radiation oncology
Special Issues and Collections in MDPI journals
Special Issue in Cells: Biology of Boron Neutron Capture Therapy (BNCT) 2021
Interests: DNA repair/DNA damage response; nucleotide excision repair; double strand break repair; DNA interstrand cross-link repair; base excision repair
DNA-targeting drugs that directly interact with DNA, such as alkylating, crosslinking, and DNA intercalating agents have been used in cancer chemotherapies for decades with some success. Recently, drugs that selectively target DNA repair factors have been developed, with some of these drugs currently under clinical trial. DNA repair inhibitors with a selective target, such as inhibitors of poly(ADP-ribose) polymerase, indirectly introduce lethal DNA damage to cancer cells. Inhibitors of epigenetic and chromatin regulation also indirectly target DNA, causing cancer cell death. DNA targeting drugs that induce lethal DNA damage directly or indirectly will become a critical component of effective cancer chemotherapies in the future. Thus, this Special Issue will focus on the use of DNA targeting drugs, namely those that target DNA repair and epigenetic and chromatin regulation, for various diseases, including cancers. Authors are invited to submit original research articles and reviews on various types of molecular and biological aspects of DNA targeting drugs for inclusion in this Special Issue.
Prof. Dr. Mitsuko Masutani
Dr. Tadayoshi Bessho
Manuscript Submission Information
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