Special Issue "The Role of Tissue-Nonspecific Alkaline Phosphatase in Inflammation and Metabolic Syndrome"
Deadline for manuscript submissions: closed (31 December 2020).
Interests: Vascular calcification; pathological bone formation; tissue-nonspecific alkaline phosphatase; inflammation; mineralization
Tissue-nonspecific alkaline phosphatase (TNAP) is mainly known for its necessary function during bone mineralization, due to the dephosphorylation of the mineralization inhibitor inorganic pyrophosphate (PPi). TNAP is however a relatively ubiquitous enzyme expressed in liver, kidney or brain that is present in the blood, both as a soluble form and at the membrane of neutrophils. Serum TNAP activity is elevated in individuals with metabolic syndrome and is associated with their increased mortality risk. This association may result from the function of TNAP in inflammation, relying on the dephosphorylation of adenosine nucleotides and lipopolysaccharide. It may also rely on the stimulation of cardiovascular calcification resulting from PPi hydrolysis in the blood and/or cardiovascular tissues.
This Special Issue of IJMS aims to cover recent findings on the regulation of TNAP during metabolic syndrome, on its inflammatory functions, and the consequences of its activation on cardiovascular mortality. Original research articles, comprehensive reviews, and short communications are all welcome.
Prof. Dr. David Magne
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- tissue-nonspecific alkaline phosphatase (TNAP)
- adenosine nucleotides
- metabolic syndrome
- vascular calcification