Special Issue "Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations 2.0"
Deadline for manuscript submissions: 31 October 2021.
Special Issues and Collections in MDPI journals
The formation of a plasma membrane was an evolutionary important achievement to attain a controlled and protected cellular milieu. However, at the same time, the presence of a plasma membrane constituted a problem because it is impermeable to charged substances and impedes free exchange of molecules, such as nutrients and metabolites. The evolution of transport systems allowed overcoming this difficulty. This Special Issue of the International Journal of Molecular Sciences is dedicated to a special class of membrane transporters: the transporters for organic cations. Organic cations are endogenous and exogenous substances, which bear a positive charge at physiological pH. Important neurotransmitters, such as acetylcholine, dopamine, histamine, and serotonin, and metabolic products, such as creatinine, are substrates of these transporters. On the other hand, since many drugs and xenobiotics are of cationic nature, transporters for organic cations can have an important pharmacological and toxicological impact. Peculiar aspects of these transporters with important structure/function correlations are their polyspecificity, the presence of several polymorphisms, and a complex regulation. This Special Issue aims to collect the newest knowledge on physiological, biochemical, pharmacological, toxicological, and pharmacogenomic aspects of transporters for organic cations.
Prof. Dr. Giuliano Ciarimboli
Manuscript Submission Information
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