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Special Issue "Toxicology of Metal Particles and OTC"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: closed (30 September 2021).

Special Issue Editor

Dr. Lorenzo Corsi
E-Mail Website
Guest Editor
Dept. Life Sciences, University of Modena and Reggio Emilia, Modena, Italy
Interests: pharmacology; cancer; toxicology, neuroscience; phytotherapy; cell biology; molecular pharmacology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The problem of environmental pollution is becoming a topic of debate in all areas of science. It is well known that environmental contaminants are threatening human health. In this scenario, the presence of antibiotic residues and their metabolites in food intended for human and animal consumption may have serious adverse effects, directly or indirectly. Indeed, some studies have revealed that widespread antibiotic use in agriculture and aquaculture might contribute to the development of resistance to antibiotics commonly used in human medicine. In addition, particular attention has been devoted to the potential toxicity of nanomaterials due to their rapid development in the last decade. Although a significant amount of scientific evidence has already described some of the potential impacts of antibiotics and nanomaterials on human health, more knowledge is needed to investigate the toxicity of specific antibiotic residuals in food, as well as metal particle exposure. Particular attention will be devoted to papers describing studies of oxytetracycline (OTC) in food as well as the toxicity of metal particles, where the molecular mechanism, the modulation of inflammatory pathways or cell transformation is reported. In vitro, in vivo and human studies that contribute to the understanding of the potential impacts of these contaminants on human health are welcome.

Dr. Lorenzo Corsi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticles
  • oxytetracycline
  • toxicology
  • inflammation
  • pollution
  • antibiotic resistance
  • cell toxicity
  • human health
  • metal particles

Published Papers (2 papers)

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Research

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Article
Dopant-Dependent Toxicity of CeO2 Nanoparticles Is Associated with Dynamic Changes in H3K4me3 and H3K27me3 and Transcriptional Activation of NRF2 Gene in HaCaT Human Keratinocytes
Int. J. Mol. Sci. 2021, 22(6), 3087; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22063087 - 17 Mar 2021
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Abstract
Despite advances in the preparation of metal oxide (MO) nanoparticles (NPs) as catalysts for various applications, concerns about the biosafety of these particles remain. In this study, we prepared transition metal-doped cerium oxide ([email protected]2; TM = Cr, Mn, Fe, Co, or [...] Read more.
Despite advances in the preparation of metal oxide (MO) nanoparticles (NPs) as catalysts for various applications, concerns about the biosafety of these particles remain. In this study, we prepared transition metal-doped cerium oxide ([email protected]2; TM = Cr, Mn, Fe, Co, or Ni) nanoparticles and investigated the mechanism underlying dopant-dependent toxicity in HaCaT human keratinocytes. We show that doping with Cr or Co but not Fe, Mn, or Ni increased the toxicity of CeO2 NPs in dose- and time-dependent manners and led to apoptotic cell death. Interestingly, while both undoped and transition metal-doped NPs increased intracellular reactive oxygen species (ROS), toxic [email protected]2 and [email protected]2 NPs failed to induce the expression of NRF2 (nuclear factor erythroid 2-related factor 2) as well as its downstream target genes involved in the antioxidant defense system. Moreover, activation of NRF2 transcription was correlated with dynamic changes in H3K4me3 and H3K27me3 at the promoter of NRF2, which was not observed in cells exposed to [email protected]2 NPs. Furthermore, exposure to relatively non-toxic [email protected]2 NPs, but not the toxic [email protected]2 NPs, resulted in increased binding of MLL1 complex, a major histone lysine methylase mediating trimethylation of histone H3 lysine 4, at the NRF2 promoter. Taken together, our findings strongly suggest that failure of cells to respond to oxidative stress is critical for dopant-dependent toxicity of CeO2 NPs and emphasize that careful evaluation of newly developed NPs should be preceded before industrial or biomedical applications. Full article
(This article belongs to the Special Issue Toxicology of Metal Particles and OTC)
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Review

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Review
Toxicological Profile of Plasmonic Nanoparticles in Zebrafish Model
Int. J. Mol. Sci. 2021, 22(12), 6372; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22126372 - 14 Jun 2021
Viewed by 756
Abstract
Plasmonic nanoparticles are increasingly employed in several fields, thanks to their unique, promising properties. In particular, these particles exhibit a surface plasmon resonance combined with outstanding absorption and scattering properties. They are also easy to synthesize and functionalize, making them ideal for nanotechnology [...] Read more.
Plasmonic nanoparticles are increasingly employed in several fields, thanks to their unique, promising properties. In particular, these particles exhibit a surface plasmon resonance combined with outstanding absorption and scattering properties. They are also easy to synthesize and functionalize, making them ideal for nanotechnology applications. However, the physicochemical properties of these nanoparticles can make them potentially toxic, even if their bulk metallic forms are almost inert. In this review, we aim to provide a more comprehensive understanding of the potential adverse effects of plasmonic nanoparticles in zebrafish (Danio rerio) during both development and adulthood, focusing our attention on the most common materials used, i.e., gold and silver. Full article
(This article belongs to the Special Issue Toxicology of Metal Particles and OTC)
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