Topical Collection "Transcriptional Regulation: Molecules, Involved Mechanisms and Misregulation"
Interests: cancer; PRDM genes; transcriptional regulation
Special Issues and Collections in MDPI journals
Special Issue in International Journal of Molecular Sciences: Transcriptional Regulation: Molecules, Involved Mechanisms and Misregulation 2019
Special Issue in International Journal of Molecular Sciences: Zinc-Finger Proteins in Health and Disease: Focus on PRDMs
Special Issue in International Journal of Molecular Sciences: Transcriptional Regulation and Its Misregulation in Human Diseases
Transcriptional regulation of gene expression in response to intra- and extracellular changes includes a series of biophysical processes controlled by innumerable transcription factors, cofactors, and chromatin regulators. This control involves multiple temporal and functional steps and levels, ranging from specific DNA–protein interactions to the recruitment and assembly of nucleoprotein complexes. The huge number of participating molecules, together with the complexity of the mechanisms, constrains the use of novel strategies to fully understand how DNA sequence information, epigenetic modifications, and transcription machinery cooperate to regulate gene expression. Recent advances in “omics” and computational biology have provided promising tools to reliably integrate different layers of information from biophysical, biochemical, and molecular cell biology studies. Thus, this Topical Collection is focused on the molecular mechanisms leading to specific gene expression patterns, with particular attention to molecules and complexes involved in transcription regulation. In particular, studies employing these novel integrated approaches will be prioritized. Additionally, research papers and review articles exploring the effects of transcriptional misregulation on human diseases are also of interest.
Dr. Amelia Casamassimi
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- transcription machinery
- nucleic acid-protein interactions
- chromatin modifying complexes
- molecular recognition
- biomolecular interactions
- posttranscriptional modifications
- transcription misregulation
- computational biophysics
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