Special Issue "Cellular and Molecular Mechanisms of Traumatic Brain Injury and Concussion"
Deadline for manuscript submissions: 20 June 2021.
Traumatic brain injury (TBI)/concussion is usually the result of an external force causing rapid acceleration and/or decelerations of the head, leading to the disruption of normal brain functions. TBI is a growing epidemic throughout the world and is considered a leading cause of disability and mortality, particularly among those younger than 45. More than 69 million individuals suffer from TBI worldwide annually. The leading causes of TBI include vehicle accidents, falls, assaults, sports-related injuries, and injuries sustained during military operations. There are two phases of injuries in TBI: the primary phase (instantaneous insult/injury) caused by the external forces; and the secondary phase (delayed or functional injury) sustained by molecular injuries which add more complexity and unpredictability/variability for short- and long-term patient management and treatment.
A wide variety of cellular and molecular mechanisms have been identified contributing to the pathogenesis of TBI. A better understanding of the pathophysiology behind TBI is essential for providing more effective treatment. The majority of neuronal death and loss often occurs in the second phase of TBI. Various detrimental processes, including inflammation, ischemia, free radical formation/oxidative stress, and excitotoxicity, are involved in the overall pathobiology of TBI.
Considering the high occurrence of TBI and its severe short- and long-term health consequences, a better understanding of underlying molecular mechanisms will definitely assist us in finding more effective diagnostic (biomarkers) tools and therapeutic interventions.
Therefore, the focus of this Special Issue of the International Journal of Molecular Sciences (IJMS) is dedicated to research and review articles to cover the latest progress in understanding molecular and cellular mechanisms of traumatic brain injury and concussion, as well as diagnostic, preventive, and therapeutic approaches for TBI.
Dr. Changiz Taghibiglou
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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- traumatic brain injury
- neurodegenrative diseases