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Special Issue "Tumor Metabolism and Signaling"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (30 April 2021).

Special Issue Editor

Dr. Niramol Savaraj
E-Mail Website
Guest Editor
University of Miami Leonard M. Miller School of Medicine, Department of Medicine, Miami, United States

Special Issue Information

Dear Colleagues,

Cancer cells are known to possess extraordinary capability to expand and survive in the harsh environment.   In order to do so, they use a number of metabolic reprogramming to ensure both fuel and building block supplies are sufficient. In fact, most tumor cells utilize “aerobic glycolysis”, the so called “Warburg effect” to generate sufficient ATP and nucleotides.  In addition, they also require amino acids to sustain their proliferation. The key amino acids which are essential for tumor cells to multiply and invade are glutamine, arginine, leucine and serine.  Tumor cells are also surrounded by immune cells, macrophages, leukocytes and fibroblasts which also require nutrients to survive and eliminate tumor cells. Thus, the dynamic between tumor cells and stromal cells/immune cells is important to determine the growth and survival of tumor cells. Tumor and immune cells /stromal cells metabolism play an important role in this process. In this issue, we plan to discuss the key aspects in tumor metabolism and signaling and how to exploit them for treatment.

Dr. Niramol Savaraj
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers

There is no accepted submissions to this special issue at this moment.
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