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Special Issue "Tumors of the Nervous System: New Insights into Signaling, Genetics and Therapeutic Targeting 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editor

Dr. Sabrina Di Bartolomeo
E-Mail Website
Guest Editor
Department of Biosciences and Territory, University of Molise, 86090 Pesche (IS), Italy
Interests: autophagy; cellular signalling; mTOR; EMT; glioma
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Brain tumors and other nervous system tumors are an extremely heterogeneous group of benign and malignant tumors characterized by different aggressiveness and variable clinical outcomes. Among them, the most common primary brain tumors in adults are gliomas, meningiomas and pituitary adenomas. Otherwise, medulloblastoma is the most common brain tumor in children. Despite their diversity, nervous system tumors share the tendency of being refractory to radical surgical resection, and radio-chemotherapy is often ineffective because of resistance mechanisms. For these reasons, clinical management of these kinds of tumors is frequently challenging and prognosis is still poor. In this scenario, precision medicine approaches are emerging as promising therapeutic avenues against nervous system tumors, and highlight the need to acquire an in-depth knowledge about the genetic mutations, signaling pathways, metabolic alterations and environmental effects involved in tumor biology and resistance to therapies.

This Special Issue focuses on the current understanding of signaling pathways, as well as genetic and epigenetic features involved in the pathogenesis of brain tumors and other nervous system tumors, with emphasis on the development of novel therapeutic approaches aimed at improving the current standard care. Original articles and up-to-date reviews are encouraged, in order to provide a comprehensive knowledge of the state of the art and future directions.

Dr. Sabrina Di Bartolomeo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • brain tumors
  • gliomas
  • medulloblastomas
  • neuroblastoma
  • cell signaling
  • molecular mechanisms
  • genetic mutations
  • cancer therapy
  • drug resistance
  • drug repositioning

Published Papers

This special issue is now open for submission.
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