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Special Issue "Advances in Cancer Metabolism and Tumour Microenvironment 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 31 January 2022.

Special Issue Editors

Prof. Dr. Karel Smetana, Jr.
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Guest Editor
1st Faculty Medicine, Institute of Anatomy and BIOCEV, Charles University, Prague 2 and Vestec, Prague, Czech Republic
Interests: tumor microenvironment; cutaneous malignant melanoma; cancer-associated fibroblasts; squamous epithelium; stem cells
Special Issues, Collections and Topics in MDPI journals
Dr. Michal Masarik
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Guest Editor
Department of Pathological Physiology, Department of Physiology, Faculty of Medicine, Masaryk University, Kamenice, 562500 Brno, Czech Republic
Interests: tumor biology; biochemistry and genetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

At the beginning of cancer research, attention was paid primarily to the characteristics of tumour cells themselves; however, the importance of the tumour microenvironment has been revealed gradually. The simple accumulation of mutations in cancer cells was shown to be insufficient for cancer progression and for the formation of metastases. On the other hand, the key mechanisms of carcinogenesis were revealed in cell communication and metabolic interactions in the tumour microenvironment. These interactions are necessary for maintaining the energy and redox balance in cancer cells and encompass literally all stages of tumour development. How cancer cells acquire and use different metabolites and reprogram their microenvironment to support tumour growth is an area of research that can have interesting therapeutic implications and a large impact on public health. Detecting metabolite level alterations in cancers may reveal an Achilles heel of cancer cells in the form of therapeutically targetable metabolic dependencies. Furthermore, because of metabolite alterations, epigenetic and gene expression changes can occur through altered DNA methylation or posttranslational protein modifications. These can lead to finding new applicable cancer biomarkers. Taken together, an altered cellular metabolism is undoubtedly a key hallmark of cancer, and an understanding of cancer metabolism will probably bring novel therapeutic approaches and new hope into cancer treatment.

Prof. Dr. Karel Smetana, Jr.
Dr. Michal Masarik
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Cancer metabolism
  • Metabolites
  • Tumour microenvironment
  • Cancer treatment
  • Tumour growth
  • DNA methylation
  • Epigenetic plasticity
  • Hallmarks of cancer

Published Papers

This special issue is now open for submission.
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