Special Issue "Ubiquitin-Conjugating or Deubiquitinating Enzymes in Signal Transduction Pathways"
Deadline for manuscript submissions: 31 March 2021.
Interests: deubiquitinating enzyme; cell proliferation; apoptosis; ubiquitin-specific protease; signal transduction
Special Issues and Collections in MDPI journals
For cellular homeostasis, the regulation of selective proteolysis is largely mediated by the posttranslational modification with the coordinated addition and removal of ubiquitin by the ubiquitin–proteasome system. Both ubiquitin-conjugating and deubiquitinating enzymes regulate the stability or function of proteins, allowing regulation of protein turnover through diverse signaling pathways. Dysregulation of these enzymes is increasingly being identified as a causative in various human diseases, such as cancers, metabolic diseases, neurodegenerative disorders, and so on. Therefore, a better understanding of the molecular mechanisms in signal transduction pathways will provide new insights into the development of more specific therapeutic approaches.
This Special Issue of the International Journal of Molecular Sciences will focus on the role of ubiquitin-conjugating and deubiquitinating enzymes including new insights into diverse signal transduction pathways, and articles submitted can either be original research works regarding these enzymes or full reviews; however, we kindly encourage authors to provide short and highly focused reviews on specific and hot topics related to human diseases.
Prof. Dr. Kwang-Hyun Baek
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- posttranslational modification
- proteasomal degradation
- protein quality control
- signaling pathway
- small molecule
- ubiquitin–proteasome system
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: The role of ubiquitin-specific-processing protease 15 (USP15) in promoting the progression of NSCLC cells through JAK/STAT3 pathway
Title: Emerging Roles of USP18: Implications in Physiology and Pathophysiology
Title: Deubiquitining Enzymes, Mitophagy, and Parkinson's Disease
Title: Post-translational modifications of retroviral HIV-1 Gag precursors: an overview of their biological role and functions
Title: Ubiquitin-Conjugating or Deubiquitinating Enzymes in Signal Transduction Pathways in periodontal disease