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Special Issue "Ubiquitin and Ubiquitin-like Molecules in Cancer"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 September 2021.

Special Issue Editor

Dr. Giuseppe Servillo
E-Mail Website
Guest Editor
Department of Medicine and Surgery, University of Perugia, Italy
Interests: molecular oncology; HOPS/TMUB1; ubiquitin-like modifier; Epigenetic gene expression; liver regeneration; apoptosis and cell cycle in cancer research; cell biology; circadian rhythms

Special Issue Information

Dear Colleagues,

Cell homeostasis is fundamental for ensuring appropriate responses to cell stress. The balance of the amount of protein in a cell is an established mechanism that guarantees the right level at the right time. The complex system of protein homeostasis plays a crucial role in cancer. Many proteins are involved in controlling the balance of protein degradation and stability. This fine-regulating mechanism is fundamental for orchestrating vital pathways such as the cell cycle, apoptosis, DNA damage and repair, and signal transduction in cell growth. Many molecules are involved in the ubiquitin–proteosome machinery, but the mechanisms are not always clear. The role of protein degradation and stability will be investigated in different aspects of cancer pathology.

This Special Issue is focused on the role played by ubiquitin-system proteins (E1–E3), deubiquitination and modifiers in cancer. It will include original articles that more deeply elucidate specific aspects of protein homeostasis in tumorigenesis. It will also consider therapeutic aspects related to the ubiquitin–proteosome machinery and relevant pharmacological advancements.

Dr. Giuseppe Servillo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cancer
  • ubiquitin
  • ubiquitin–proteosome machinery
  • ubiquitin ligases (E3s)
  • DUBs
  • ubiquitin-like (UBL)

Published Papers

This special issue is now open for submission.
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