Topical Collection "The Use of In Vitro and In Vivo Models for Research on Bioactive Compounds"
2. Associated Unit of R&D and Innovation CEBAS-CSIC+UPCT on “Quality and Risk Assessment of Foods”, CEBAS-CSIC, Campus Espinardo - 25, E-30100 Murcia, Spain
Interests: food science and technology; phytochemistry; bioactive compounds; health-promoters, functional ingredients; natural foods; healthy foods; energy metabolism (obesity and diabetes); human nutrition; wellbeing
Special Issues and Collections in MDPI journals
Special Issue in Molecules: Bioactives and Functional Ingredients in Foods and Beverages
Special Issue in Foods: Climate Changes and Global Warming—the Future of Foods
Special Issue in International Journal of Molecular Sciences: Vesicular Encapsulation of Bioactives and Nutraceuticals—Advantages and Applications
Special Issue in Foods: Selected Papers from the 1st International Electronic Conference on Food Science and Functional Foods (Foods 2020)
Special Issue in Foods: Selected Papers from the 2nd International Electronic Conference on Foods - "Future Foods and Food Technologies for a Sustainable World" (Foods 2021)
Interests: lipidomics; plant oxylipins; bioaccessibility; bioavailability; bioactivity; structure-activity relationship (SAR); in vitro models of biological activity; inflammation; oxidative stress; immune system
Special Issues and Collections in MDPI journals
Special Issue in Foods: New Insights in (Poly)Phenolic Compounds: From Dietary Sources to Health Evidences
Special Issue in Molecules: Contributions of Bioactive Compounds to Quality, Safety, and Bioactivity of Plant Foods
Special Issue in Foods: Taking Advantage of Lipidomic Approaches to Unravel the Biological Activities of Plant-Based Foods
Interests: immunology; inflammation; macrophages; cell biology; in vitro models for drug development; cirrhosis; endometriosis; diabetes; insulin resistance
To address the current challenges in the scientific validation of the functionality of bioactive compounds for health and well-being, there is a need for novel approaches and research results focused on the clarification, elucidation, and investigation of the structure–function relationships and the design of better dietary and clinical interventions to back up their potential functionality. Therefore, in this Special Issue of IJMS, we aim to assemble a topical collection of publications, communications, insightful and critical information, research results, and opinions on the state-of-the-art investigations using in vitro and in vivo models as preclinical research stages for the investigation of potentially bioactive compounds.
Moreover, we aim to provide an ideal platform for the discussion of the findings of epidemiological and clinical studies lacking this necessary preclinical information to foster future validation of functionalities. Many clinical results are lacking enough strength to validate a “functional” compound, ingredient, or food because of the gap of knowledge on the structure–function relationship due to insufficient bioactivity demonstration, and this Topical Collection aims to make results that fill this gap available in open access so that the research community worldwide may benefit.
We welcome the submission of studies considering the development, establishment, and validation of in vitro and in vivo models for the study of health-promoting bioactive compounds at the physiological, biochemical, and molecular levels in order to find the connection between the compounds in their natural matrices (extracted, purified, or formulated) and the potential effects on health and well-being through improvements in bioaccessibility, bioavailability, metabolism, and bioactivity.
Dr. Diego A. Moreno
Dr. Raúl Domínguez-Perles
Dr. Antonio J. Ruiz-Alcaraz
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- cell assay
- animal models
- in silico models
- immune system