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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic. The journal’s Editor-in-Chief and/or designated EBM will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Molecular and Cellular Mechanisms of Neurodegenerative Diseases 2.0
edited by
submission deadline 20 Sep 2024 | 1 articles | Viewed by 1557 | Submission Open
Keywords: neurodegenerative diseases; Alzheimer’ s disease (AD); Parkinson’ s disease (PD); frontotemporal lobar degeneration (FTLD); amyotrophic lateral sclerosis (ALS); Huntington’ s disease (HD); prion diseases; cellular and molecular mechanisms; omics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Inflammatory Bowel Disease: Molecular Insights
edited by
submission deadline 20 Sep 2024 | 2 articles | Viewed by 1503 | Submission Open
Keywords: genomic sequencing; microbiome; dysbiosis; commensal flora; omics; immunobiology; colitis; Crohn’ s disease; ulcerative colitis; multiomics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Precision Medicine for Oral Diseases and Cancers
edited by Marina Di Domenico and
submission deadline 20 Sep 2024 | 2 articles | Viewed by 1473 | Submission Open
Keywords: cancer; laboratory medicine; personalized medicine; diagnostic; machine learning; precision medicine; stem cells; oral diseases; clinical biochemistry; translational medicine; geometry optimization of biomaterials; cell adhesion; computational mechanobiology; bioengineering; bioscaffolds; systemic diseases; general health; quality of life; microbiota
(This special issue belongs to the Section Molecular Pharmacology)
Bioprocesses and Biotechnology Related to Extremophiles—Molecular Aspects submission deadline 20 Sep 2024 | 2 articles | Viewed by 1451 | Submission Open
Keywords: waste circularity; plastic recycle; lignocellulose; extremozymes; microbial ecology; microbial bioprocess
(This special issue belongs to the Section Molecular Microbiology)
New Insights into Lactoferrin
edited by and
submission deadline 20 Sep 2024 | 1 articles | Viewed by 1379 | Submission Open
Keywords: lactoferrin; lactoferrin structure; lactoferrin functions; infection; inflammation; iron homeostasis; oxidative stress; lactoferrin bioavailability
(This special issue belongs to the Section Molecular Immunology)
Molecular Research of Endocytic and Autophagic Pathways in Diseases submission deadline 20 Sep 2024 | 1 articles | Viewed by 1342 | Submission Open
Keywords: autophagy; endocytic pathway; endosome; multivesicular body; autophagosome endosomal– lysosomal system; extracellular vesicles; intracellular trafficking pathways; membrane fusion; metabolism
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Pharmacogenomics 3.0
edited by
submission deadline 20 Sep 2024 | 2 articles | Viewed by 1283 | Submission Open
Keywords: pharmacogenomics of cardiovascular disorders; pharmacogenomics of cancer; pharmacogenomics of brain disorders; pharmacogenomics of metabolic and endocrine disorders; pharmacogenomics of gastrointestinal disorders; pharmacogenomics of lipid metabolism disorders; pharmacoepigenomics of pain; pharmacogenomics of psychotropic drugs; neurodegenerative disorders (Alzheimer; Parkinson; multiple sclerosis)
(This special issue belongs to the Section Molecular Pharmacology)
Calcium Homeostasis of Cells in Health and Disease 2.0 submission deadline 20 Sep 2024 | 1 articles | Viewed by 1246 | Submission Open
Keywords: Ca2+; calcium homeostasis; calcium-binding proteins; aging; disease
(This special issue belongs to the Section Biochemistry)
CoA in Health and Disease 3.0
edited by
submission deadline 20 Sep 2024 | 1 articles | Viewed by 1228 | Submission Open
Keywords: energy production; impaired metabolism; Acyl-CoA synthesis and function; Acetyl-CoA; CoA analogues; oxidative stress; hereditary diseases
(This special issue belongs to the Section Biochemistry)
Molecular Research and Treatment of Breast Cancer 3.0
edited by
submission deadline 20 Sep 2024 | 1 articles | Viewed by 1211 | Submission Open
Keywords: biomarkers; breast cancer; cancer stem cells; cell signaling; circulating tumor cells; drug discovery; molecular diagnostics; molecular profiling; targeted therapy; therapy resistance
(This special issue belongs to the Section Molecular Oncology)
Molecular Research on Inflammatory Diseases of the Gut in Humans and Animals submission deadline 20 Sep 2024 | 1 articles | Viewed by 1142 | Submission Open
Keywords: gene; epigenetic; biomarker; intestinal; gut; IBD; mycobacterium avium; Johne’ s disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Regulation on Nutrient Sensing, Signaling and Transport in Plants
edited by
submission deadline 20 Sep 2024 | 1 articles | Viewed by 1074 | Submission Open
Keywords: macronutrient; micronutrient; toxic metal; sensing; signaling; transport; phytoremidiation; model plants; crops; climate change
(This special issue belongs to the Section Molecular Plant Sciences)
Next-Generation Sequencing and Whole-Genome Sequencing in Molecular Research
edited by
submission deadline 20 Sep 2024 | 1 articles | Viewed by 1067 | Submission Open
Keywords: high-throughput sequencing; whole-genome sequencing; big data; machine learning; artificial intelligence; predictive modeling; transformative technology; investigative and diagnostic tools
(This special issue belongs to the Section Molecular Informatics)
Molecular Mechanisms and Pharmacological Approaches for Brain Injury
edited by
submission deadline 20 Sep 2024 | 1 articles | Viewed by 1049 | Submission Open
Keywords: molecular mechanisms; therapeutical effects; brain injury; stroke; inflammation; autophagy; drug discover; target validation
(This special issue belongs to the Section Molecular Pharmacology)
Current Research in Antimicrobial Natural Products
edited by Jose Javier Sanz Gomez
submission deadline 20 Sep 2024 | 1 articles | Viewed by 1028 | Submission Open
Keywords: natural products; chemical composition; spoilage microorganisms; pathogens; food preservatives; biofilms; safety assessment; clean label; antibiotics resistance
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Targeting Corneal Wound Healing: Molecular Access to Diagnosis, Pathophysiology, and Treatment
edited by
submission deadline 20 Sep 2024 | 1 articles | Viewed by 1011 | Submission Open
Keywords: corneal wound healing; optical visual performance; cornea; extracellular matrix; enzymatic activities; growth factors; cytokines
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Diagnostic Tools and Biomarkers in Oncological Diseases 2.0
edited by
submission deadline 20 Sep 2024 | 1 articles | Viewed by 968 | Submission Open
Keywords: oncologic diseases; biomarkers; liquid biopsy; miRNA; ncRNA; exosomes
(This special issue belongs to the Section Molecular Oncology)
Natural Products as Multitarget Agents in Human Diseases submission deadline 20 Sep 2024 | 1 articles | Viewed by 932 | Submission Open
Keywords: natural products; bioactive compounds; human health; disease prevention and treatment; molecular and physiological mechanism; inflammatory diseases; cancer; arthritic diseases  
(This special issue belongs to the Section Molecular Pharmacology)
SMART and Macromolecular Biomaterials: From Materials to Biology 2.0 submission deadline 20 Sep 2024 | 1 articles | Viewed by 925 | Submission Open
Keywords: biomaterials; SMART materials; cytocompatibility; biocompatibility; technology
(This special issue belongs to the Section Macromolecules)
Properties and Applications of Nanoparticles and Nanomaterials
edited by Xiaogang Li
submission deadline 20 Sep 2024 | 1 articles | Viewed by 922 | Submission Open
Keywords: nanostructures; nanoparticles; microstructure characterization; material design; evaluation of mechanical properties; applications of nanomaterials
(This special issue belongs to the Section Molecular Nanoscience)
Vaccination against Enterobacteriaceae: From Pre-clinical Models to Translation
edited by
submission deadline 20 Sep 2024 | 1 articles | Viewed by 868 | Submission Open
Keywords: enterobacteriaceae; (mucosal) vaccines; immunity; intestinal microbiota; dysbiosis; microbial pathogenesis; animal models
(This special issue belongs to the Section Molecular Microbiology)
Predictive, Prognostic Biomarkers and Therapeutic Targets of Breast Cancer
edited by Antonella Ciabattoni and Fabiana Gregucci
submission deadline 20 Sep 2024 | 1 articles | Viewed by 825 | Submission Open
Keywords: radiotherapy; breast cancer; stereotactic body radiotherapy; brain radiosurgery; target therapy; immunotherapy; tailored systemic therapy
(This special issue belongs to the Section Molecular Oncology)
Chemical Bond and Bonding: Fundamental Aspects and Recent Developments
edited by Sudip Pan
submission deadline 20 Sep 2024 | 1 articles | Viewed by 816 | Submission Open
Keywords: bonding; covalent bond; coordination bond; non-covalent bond; metallic and ionic bond; hydrogen bond; halogen bond; chalcogen bond; weak bonding
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Evidence-Based Principles of Diagnosis and Management of Hypertension in Modern Era submission deadline 20 Sep 2024 | 1 articles | Viewed by 811 | Submission Open
Keywords: primary hypertension; secondary hypertension; gestational hypertension; renin angiotensin aldosterone system; metabolic syndrome; salt overload
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Metal Toxicity in Animals: Recent Insights on Physiological and Molecular Aspects
edited by
submission deadline 20 Sep 2024 | 1 articles | Viewed by 788 | Submission Open
Keywords: heavy metals; lanthanides; physiological and molecular pathways of cellular toxicology; environmental pollution; risk assessments; risk of mixing contaminants
(This special issue belongs to the Section Molecular Toxicology)
Molecular Research in Plant Adaptation to Abiotic Stress submission deadline 20 Sep 2024 | 1 articles | Viewed by 692 | Submission Open
Keywords: NO; H2S; H2O2; GABA; phytohormones; salinity; high and low temperatures; dehydration; drought; oxidative stress
(This special issue belongs to the Section Molecular Plant Sciences)
Traumatic Brain Injury/Chronic Traumatic Encephalopathy as Cause of Alzheimer’s Disease: Physics and Molecular Biology in the Genesis of Neurodegeneration?
edited by
submission deadline 20 Sep 2024 | 1 articles | Viewed by 652 | Submission Open
Keywords: traumatic brain injury (TBI); chronic traumatic encephalopathy (CTE); head impacts; Alzheimer's disease (AD); neurodegeneration
(This special issue belongs to the Section Molecular Neurobiology)
Cell Division: A Focus on Molecular Mechanisms
edited by Stefano Sechi and Antonino Colanzi
submission deadline 20 Sep 2024 | 1 articles | Viewed by 600 | Submission Open
Keywords: cell cycle; cell division; post-translational modification (PTM); mitosis/meiosis; cell organelles; cytokinesis; membrane trafficking; disease; therapeutic target; model organisms
(This special issue belongs to the Section Molecular Biology)
Antimicrobial and Antiviral Peptides
edited by
submission deadline 20 Sep 2024 | Viewed by 461 | Submission Open
Keywords: antimicrobial peptides; antiviral peptides; peptide mining; molecular mechanism of biological activity; structure– activity relationship; molecular targets; in silico design; in vivo models; peptide delivery strategies; biomedical applications
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Pathways and New Therapies for Breast Cancer
edited by
submission deadline 20 Sep 2024 | Viewed by 408 | Submission Open
Keywords: breast cancer; cell signaling; molecular heterogeneity; targeted therapies; HER2; biomarkers
(This special issue belongs to the Section Molecular Biology)
The Road to Tolerance: Mechanism of Immune Homeostasis in Health and Disease
edited by
submission deadline 20 Sep 2024 | Viewed by 376 | Submission Open
(This special issue belongs to the Section Molecular Immunology)
New Advances in Myocardial Regeneration: Molecular Mechanisms and Promising Approaches
edited by
submission deadline 20 Sep 2024 | Viewed by 337 | Submission Open
Keywords: myocardial regeneration; transplantation of cells; proliferation of cardiomyocytes; 3D bioprinting; single cell omics; exosome delivery; cardiac organoids; direct reprogramming
(This special issue belongs to the Section Molecular Biology)
The Molecular and Cellular Aspects of Insulin Resistance submission deadline 20 Sep 2024 | Viewed by 324 | Submission Open
Keywords: insulin resistance; insulin receptor; IRS; Akt; PI3K; protein phosphorylation; protein dephosphorylation; inflammation; metabolic syndrome; cardiometabolic syndrome; diabetic cardiomyopathy
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Immunomodulatory Activities of Natural Products and Related Compounds in Inflammatory Diseases
edited by Horyue Tan
submission deadline 20 Sep 2024 | Viewed by 320 | Submission Open
Keywords: immunomodulatory; natural products; inflammatory diseases; chronic inflammation
(This special issue belongs to the Section Molecular Immunology)
Molecular Research on Nanosorbent Materials submission deadline 20 Sep 2024 | Viewed by 314 | Submission Open
Keywords: adsorption; adsorbents; nanomaterials; insight at the molecular level; experimental studies; theoretical studies; fundamentals; applications
(This special issue belongs to the Section Materials Science)
Molecular Study of Renal Diseases submission deadline 20 Sep 2024 | Viewed by 309 | Submission Open
Keywords: digital pathology; computational pathology; spatial biology; renal biopsy; chronic kidney disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Blood-Brain Barrier in Neuroinflammation and Neurological Diseases
edited by
submission deadline 20 Sep 2024 | Viewed by 296 | Submission Open
Keywords: blood-brain barrier; in vitro model; in vivo model; pathology; blood– spinal cord barrier; blood– CSF barrier; blood– nerve barrier; multiple sclerosis; neuromyelitis optica; Alzheimer’ s disease; Parkinson’ s disease; collagen disease; autoimmune encephalitis; amyotrophic lateral sclerosis; trauma; diabetes; cerebral small vessel disease; neuropathic pain; autoimmune neuropathy
(This special issue belongs to the Section Molecular Neurobiology)
50th Anniversary of the Molten Globule Prediction: The Impact on the Protein Folding Problem submission deadline 20 Sep 2024 | Viewed by 285 | Submission Open
Keywords: protein folding; cotranslational folding; chaperone-assisted folding; protein denaturation; protein unfolding; protein refolding; partially folded protein; folding intermediate; molten globule; protein misfolding; protein aggregation; conformational disease
(This special issue belongs to the Section Molecular Biophysics)
Planetary Health: The Molecular Perspective of Environmental Changes Impacting on Cardiovascular Function submission deadline 20 Sep 2024 | Viewed by 282 | Submission Open
Keywords: cardiovascular function; environmental changes; molecular mechanisms  
(This special issue belongs to the Section Molecular Biology)
Molecular Advances in Gastric Cancer
edited by Su-youn Nam
submission deadline 20 Sep 2024 | Viewed by 275 | Submission Open
Keywords: gastric cancer; molecular biomarker; sequencing; organoid; metabolic marker
(This special issue belongs to the Section Molecular Oncology)
Advances in Structure, Function and Molecular Targeting of DNA Topoisomerases 2.0
edited by Joseph E. Deweese and Neil Osheroff
submission deadline 20 Sep 2024 | Viewed by 257 | Submission Open
Keywords: topoisomerase; DNA supercoiling; DNA topology; anticancer; antimicrobial; DNA damage
(This special issue belongs to the Section Molecular Biology)
Antibody Therapy for Hematologic Malignancies submission deadline 20 Sep 2024 | Viewed by 256 | Submission Open
Keywords: hematologic malignancies; leukemia; lymphoma; antibody therapy; immune therapy; cellular therapy; combination therapy; bispecific; BiTE; trispecific; tumor antigens; Fc receptors; signaling; microenvironment
(This special issue belongs to the Section Molecular Oncology)
Recent Progress with Duchenne Disease: From Molecular Pathology to Therapies
edited by
submission deadline 20 Sep 2024 | Viewed by 254 | Submission Open
Keywords: duchenne and becker muscular dystrophy; DMD transcript studies; molecular mechanisms; translational medicine; biology of myopathies; DMD gene therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genomics and Proteomics of Cancer Cell Survival and Development submission deadline 20 Sep 2024 | Viewed by 248 | Submission Open
(This special issue belongs to the Section Molecular Oncology)
Genetic Insights into Host-Viral Response and Pathogenesis 2.0
edited by
submission deadline 20 Sep 2024 | Viewed by 245 | Submission Open
Keywords: viruses; host– virus interaction; genetics; molecular aspects; epigenetics; immunity; prevention; drug-treatments; vaccine development
(This special issue belongs to the Section Molecular Genetics and Genomics)
Toxic Effects of Cancer Treatments: Update on Targeted Molecular Approaches and Signalling Pathways
edited by and Éric Morel
submission deadline 20 Sep 2024 | Viewed by 232 | Submission Open
Keywords: radiotherapy; cancer treatment; chemotherapy; toxicities; hormone therapy; molecular signaling pathway
(This special issue belongs to the Section Molecular Toxicology)
Research on the Growth and Development of Germ Cells
edited by
submission deadline 20 Sep 2024 | Viewed by 223 | Submission Open
Keywords: follicle development; premature ovarian insufficiency; signal transduction; apoptosis autophagy; aging; reproductive biotechnology; organ-on-chip
(This special issue belongs to the Section Molecular Biology)
Advances and Perspectives in Molecular Tumor Therapy
edited by
submission deadline 20 Sep 2024 | Viewed by 217 | Submission Open
Keywords: tumorigenesis; immunotherapy; targeted therapy; tumor microenvironment; anti-cancer drugs
(This special issue belongs to the Section Molecular Oncology)
Molecular Insights into Platelet Biology and Function submission deadline 20 Sep 2024 | Viewed by 215 | Submission Open
Keywords: platelets; thrombosis; hemostasis; reactivity
(This special issue belongs to the Section Molecular Biology)
Recent Advances in the Immunopathology, Diagnostic Biomarkers, Susceptibility and Potential Therapies for Adverse Reactions to Food
edited by
submission deadline 20 Sep 2024 | Viewed by 215 | Submission Open
Keywords: adverse reactions to food; food intolerance; food allergy; gastrointestinal tract disorders; food hypersensitivity classification
(This special issue belongs to the Section Molecular Immunology)
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