Special Issue "Metal-Based Antimicrobials"

A special issue of Inorganics (ISSN 2304-6740). This special issue belongs to the section "Bioinorganic Chemistry".

Deadline for manuscript submissions: 30 December 2021.

Special Issue Editors

Prof. Dr. Miloš I. Djuran
E-Mail Website
Guest Editor
1. Department of Chemistry, Faculty of Science, University of Kragujevac, R. Domanovića 12, P.O.Box 60, 34000 Kragujevac, Serbia
2. Serbian Academy of Sciences and Arts, Knez Mihailova 35, 11000 Belgrade, Serbia
Interests: coordination chemistry of transition metal ions; structural characterization of transition metal complexes; transition metal complexes as antitumor and antimicrobial agents; platinum(II) and palladium(II) complexes as potential reagents for regioselective hydrolysis of peptides and proteins; interaction of transition metal complexes with biomolecules in correlation to the mechanism of their biological activity
Dr. Jasmina Nikodinović-Runić
E-Mail Website
Guest Editor
Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade, 11010 Belgrade, Serbia
Interests: microbial biotechnology; biological polymers; biocatalysis; bioremediation; bioactive molecules; antimicrobials
Special Issues, Collections and Topics in MDPI journals
Dr. Biljana Đ. Glišić
E-Mail Website
Guest Editor
Department of Chemistry, Faculty of Science, University of Kragujevac, R. Domanovića 12, 34000 Kragujevac, Serbia
Interests: medicinal inorganic chemistry; metal complexes; gold complexes; silver complexes; nitrogen-donor ligands; peptides; DNA interactions; protein interactions; antimicrobial agents

Special Issue Information

Dear Colleagues,

Infectious diseases are becoming increasingly difficult to treat, because many microbes have developed resistance to clinically used antimicrobials. Antimicrobial resistance is especially correlated with the presence of biofilms, because in this form, microbes manifest up to one thousand times higher resistance. It is estimated that antimicrobial resistance causes at least 50 thousand deaths each year in Europe and the United States, and that it will cause 10 million deaths worldwide per year by 2050. Therefore, the development of new antimicrobial agents is of paramount importance. Metal complexes might represent a novel class of antimicrobial agents because of their favorable features compared with organic compounds, including enhanced stereochemistry and reactivity, lipophilicity, and different modes of action.

This Special Issue aims to highlight the progress in the field of the synthesis of novel metal complexes as potential antimicrobial agents, and investigation of their interactions with biological targets.  

Prof. Dr. Miloš I. Djuran
Dr. Jasmina Nikodinović-Runić
Dr. Biljana Đ. Glišić
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Inorganics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • medicinal inorganic chemistry
  • drug discovery and development
  • antimicrobial resistance
  • metal complexes
  • synthesis and structural characterization
  • antimicrobial activity
  • biofilms
  • mechanism of antimicrobial activity
  • interaction with biomolecules
  • structure-activity relationship

Published Papers (1 paper)

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Review

Review
Strike a Balance: Between Metals and Non-Metals, Metalloids as a Source of Anti-Infective Agents
Inorganics 2021, 9(6), 46; https://0-doi-org.brum.beds.ac.uk/10.3390/inorganics9060046 - 04 Jun 2021
Viewed by 920
Abstract
Most of the commercially available anti-infective agents are organic molecules. In fact, though, during the pioneering times of modern medicine, at the beginning of the 20th century, several inorganic compounds of transition metals were used for medicinal application, to date, only a small [...] Read more.
Most of the commercially available anti-infective agents are organic molecules. In fact, though, during the pioneering times of modern medicine, at the beginning of the 20th century, several inorganic compounds of transition metals were used for medicinal application, to date, only a small number of inorganic drugs are used in clinical practice. Beyond the transition metals, metalloids—or semimetals—offer a rich chemistry in between that of metallic and non-metallic elements, and accordingly, peculiar features for their exploitation in medicinal chemistry. A few important examples of metalloid-based drugs currently used for the treatment of various diseases do exist. However, the use of this group of elements could be further expanded on the basis of their current applications and the clinical trials they entered. Considering that metalloids offer the opportunity to expand the “chemical-space” for developing novel anti-infective drugs and protocols, in this paper, we briefly recapitulate and discuss the current applications of B-, Si-, As-, Sb- and Te-based anti-infective drugs. Full article
(This article belongs to the Special Issue Metal-Based Antimicrobials)
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