Special Issue "G Protein-Coupled Receptors and Their Effects in Cardiovascular Disease, Cancer and Neurodegeneration"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiovascular Medicine".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editor

Dr. Alessandro Cannavo
E-Mail Website
Guest Editor
Department of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, Italy
Center for Translational Medicine, Temple University, Philadelphia, PA 19140, USA
Interests: Cardiovascular Disease; G protein coupled receptor; Neurodegenerative disorders; Periodontitis; Pharmacology
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Cardiovascular and neurodegenerative disorders, as well as cancer, have become a growing pandemic for older subjects. No treatment is available that can stop the progression of these chronic diseases, and massive increases in healthcare costs are predicted in the coming years. Understanding the molecular mechanisms involved in the pathogenesis of these diseases affords the basis for identifying druggable targets. Furthermore, it will aid the development of novel treatments aimed at halting the decline in daily functional activities and improving older adults' quality of life.

Over the past three decades, G protein-coupled receptors (GPCRs) and their signaling pathways have been intensely studied for their influence in almost every aspect of mammals physiology. Their role in the pathogenesis of the aforementioned chronic disorders is of high interest; hence, drugs targeting different GPCRs have been developed and approved to be used in clinical practice to treat cardiovascular, neurological disorders, and cancer.

The  primary goal of this Special Issue is to inform the readers about the most advanced knowledge of how GPCRs and their signaling pathways influence almost every aspect of cardiovascular disease, neurodegenerative disorders, and cancer.

This Special Issue welcomes the submission of both original research articles and reviews presenting the readers of the Journal of Clinical Medicine an update on the following sub-topics:

(1) GPCRs and their signaling pathways involved in the pathogenesis of cardiovascular disorders, neurodegeneration, and cancer;

(2) Novel therapeutic strategies aimed at targeting GPCRs and their downstream signaling pathways to prevent or slow the development and progression of cardiovascular disorders, neurodegeneration, and cancer.

Dr. Alessandro Cannavo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Heart Failure
  • Parkinson's disease
  • Alzheimer's disease
  • cellular signaling
  • GPCR

Published Papers

This special issue is now open for submission.
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