Special Issue "Should Physicians Consider NAFLD a Primary or Secondary Disease?"
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".
Deadline for manuscript submissions: closed (10 March 2021).
Interests: nonalcoholic fatty liver disease; metabolic syndrome; obesity; atherosclerosis and NAFLD; PCOS and NAFLD; HCV-related chronic hepatitis; HCV-related arthritis; therapy of liver cirrhosis; portal hypertension; hepatic encephalopathy; imaging ultrasonography of liver and spleen; psoriatic arthritis and NAFLD; cytokines in obesity
Special Issues and Collections in MDPI journals
Special Issue in Diagnostics: Diagnosing NAFLD: Which Tool, Where, When and Why to Use It
Special Issue in International Journal of Molecular Sciences: Thyroid Hormones and NAFLD: New Insights
Special Issue in International Journal of Molecular Sciences: Thyroid Hormones and NAFLD: New Insights 2.0
Obesity, dyslipidemia, hypertension, and type 2 diabetes mellitus (T2DM) are mostly prominent in Western societies (but are not restricted to these), and represent the well-known metabolic syndrome. Focusing on obesity, there is a great body of evidence that both genetic and environmental factors are important in its genesis and evolution. Whereas the genetic factors are still poorly understood, numerous studies have shown that particularly abdominal obesity and physical inactivity are central. Specifically, obesity is a major risk factor for the development of insulin resistance—a key factor in the etiology of the metabolic syndrome and T2DM. Obesity and insulin resistance promote the development of non-alcoholic fatty liver disease (NAFLD), which in a subset of patients can evolve in a more severe form (i.e., non-alcoholic steatohepatitis, NASH). NASH is characterized by fatty infiltration of the liver and inflammation leading to the apoptosis and necrosis of hepatocytes—features to which reparative responses follow, resulting in fibrosis. Unfortunately, research is far from completely clarifying the genesis of these diseases (NAFLD/NASH) and suggesting appropriate therapy to drastically reduce or eliminate them. Finally, there is still much debate as to whether NAFLD/NASH is a primary or secondary illness.
This Special Issue is set to gather research concerning the unknown mechanisms of these diseases and to confirm the consolidated ones with new observations.
Potential topics include but are not limited to the following:
- Obesity-related NAFLD;
- Non-obese NAFLD;
- Genetic NAFLD;
- Re-feeding NAFLD;
- PCOS-associated NAFLD;
- OSAS-associated NAFLD;
- Drug-induced NAFLD (including toxic substances);
- Juvenile NAFLD;
- Silent NASH;
- Is NAFLD really benign?
- The role of metabolic syndrome in the onset and worsening of NAFLD;
- The link between NAFLD and hepatocarcinoma;
- Immune system involvement, with special attention to the major immune organ (i.e., spleen);
- Chronic low-grade inflammation;
- Adipokines, hormones, and growth factors involved in the pathogenesis of NAFLD/NASH;
- Mitochondrial dysfunction at the basis of NAFLD;
- The interplay between microbiome and/or virome and NAFLD;
- Environmental factors linked to NAFLD;
- The emerging role of MUFAs.
Prof. Dr. Giovanni Tarantino
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Obesity- related NAFLD
- Non obese NAFLD
- Genetic NAFLD
- Metabolic Syndrome
- Chronic low-grade inflammation
- Inmune system involvement
- Adipokines (mechanisms)
- Cytokines (mechanisms)
- Hormones and Growth Factors (mechanisms)