Special Issue "Molecular Biology of Ovarian Cancer"
Deadline for manuscript submissions: closed (31 December 2020).
Interests: hCG; placenta; reproductive immunology; gynecologic oncology; glycoproteins
Special Issues and Collections in MDPI journals
Special Issue in International Journal of Molecular Sciences: Reproductive Immunology: Cellular and Molecular Biology
Special Issue in International Journal of Molecular Sciences: Reproductive Immunology: Cellular and Molecular Biology 2.0
Special Issue in Medicina: Immunologic Checkpoint Molecules and Their Role in Reproduction and Cancer
Epithelial ovarian cancer (EOC) represents the most lethal malignancy of the female genital tract. Nowadays, ovarian cancer patients’ prognosis mostly relies on the completeness of surgical tumor resection, clinical staging, and histological tumor grading. Thus, there is a compelling need to identify and validate tumor-specific mechanisms and molecules that are suitable to individualize therapeutic strategies. Interestingly, during EOC evolvement and progression, host anti-tumor immune defence seems to be actively blocked by tumor-derived mediators. By creating this highly suppressive environment, EOC manages to extensively grow and spread in the peritoneal cavity. In addition, recommended therapeutic approaches include beneath primary cytoreductive surgery, a platinum-based chemotherapy with anti-angiogenic agents, or PARP inhibitors. EOC is classified as serous, mucinous, endometrioid, and clear-cell histology, being distinguished in terms of phenotype, molecular background, and aetiology. Research to identify new molecular prognostic markers needs to take this heterogeneity of ovarian cancer into account. A better understanding of the different mechanisms in ovarian cancer subtypes appears crucial to enable new diagnostic and therapeutic approaches.
Prof. Dr. Udo Jeschke
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- Epithelial ovarian cancer (EOC)
- Tumor-specific mechanism
- Heterogeneity of ovarian cancer
- Tumor-immune cell micro environment
- New therapeutic strategies in EOC treatment.