Dissecting the Relationship between Personality Disorders and Suicide

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Mental Health".

Deadline for manuscript submissions: closed (1 August 2022) | Viewed by 14165

Special Issue Editor


E-Mail
Guest Editor
Department of Psychiatry, Puerta de Hierro University Hospital, Health Research Institute Puerta de Hierro-Segovia de Arana (IDIPHISA), Majadahonda, Madrid, Spain
Interests: suicidal behavior; personality disorders; ADHD; psychopharmacology; biomarkers; nutrition
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The prevalence of personality disorders (PDs) is approximately 10% worldwide. A combination of genetic factors and difficult life experiences, particularly chilhood maltreatment, contribute to PD development. PDs are associated with a high risk of suicidal behavior (SB) and death by suicide. However, the impact of PDs on SB and SB-related behaviors (e.g., self-harm, suicidal gestures) is underestimated. Indeed, with the remarkable exception of borderline personality disorder (BPD), the role of other PDs has scarcely been studied. For instance, suicide is a clinically significant but underevaluated cause of mortality in narcissistic PD (NPD). Indeed, there are no reliable estimates of SB for this population. Moreover, certain life events (LEs) can precipitate SB in patients with a PD, but the question about specific putative combinations of LEs and PDs increasing suicidal risk remains poorly studied. In addition, PDs distinguish between suicide attempters and completers. Thus, suicide completers and suicide attempters are more likely to be diagnosed with NPD and BPD, respectively. Moreover, schizoid PD is related to medically serious suicide attempts. These findings emphasize the relevance of implementing prevention programs tailored to suicide attempters and completers.

With the advent of the ICD-11, the classification of PDs is no longer categorical but dimensional. With the exception of BPD, all distinct PD categories from ICD-10 are missing. A PD is defined by the severity of the disorder. Indeed, some authors have argued that a PD’s severity might be more useful in estimating suicide risk than the use of specific PD categories. From the perspective of child and adolescent psychiatry, ICD-11 removed the age limit. Accordingly, PDs can be diagnosed across the lifespan, thus offering a new perspective on the relationship between PDs and suicide in adolescents.

The aim of this Special Issue is to provide up-to-date information on the relationship between PD and suicide. We are particularly interested in novel and disruptive approaches, such as: 1) the role of a PD in processing and tolerating the mental pain that leads to suicide; 2) the contribution of a PD to the presuicidal syndrome across the lifespan, but particularly during life-cycle transitions (adolescence, middle age, or elderly age); and 3) novel tools (e.g., big data, data mining, artificial intelligence) applied to novel sources of information (e.g., social media) to disentangle the relationship bertween PD and suicide in the 21st century.

Dr. Hilario Blasco-Fontecilla
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • personality traits
  • personality disorders
  • self-harm
  • non-suicidal self injury (NSSI)
  • suicidal behavior (SB)
  • suicide attempts (SA)
  • suicide gestures
  • parasuicide
  • suicide
  • mental pain

Published Papers (5 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Jump to: Review

10 pages, 675 KiB  
Article
Comparing Differences between Two Groups of Adolescents Hospitalized for Self-Harming Behaviors with and without Personality Disorders
by Ping Wang, Chao Li, Marcos Bella-Fernández, Marina Martin-Moratinos, Leticia Mallol Castaño, Pablo del Sol-Calderón, Mónica Díaz de Neira and Hilario Blasco-Fontecilla
J. Clin. Med. 2022, 11(24), 7263; https://0-doi-org.brum.beds.ac.uk/10.3390/jcm11247263 - 07 Dec 2022
Cited by 1 | Viewed by 1156
Abstract
Self-harm (non-suicidal self-injury (NSSI) and suicidal behavior (SB)) is frequent display during adolescence. Patients with personality disorders (PDs) frequently self-harm. However, few studies have focused on the role of PDs in self-harming adolescents. In this study, we collected 79 adolescents hospitalized due to [...] Read more.
Self-harm (non-suicidal self-injury (NSSI) and suicidal behavior (SB)) is frequent display during adolescence. Patients with personality disorders (PDs) frequently self-harm. However, few studies have focused on the role of PDs in self-harming adolescents. In this study, we collected 79 adolescents hospitalized due to self-harm (88.6% female; 78.5% Caucasian) and divided them into two groups, with or without a diagnosis of PD. The socio-demographic and psychological-clinical data were collected through a structured interview by clinicians. Univariate, subgroup, and multiple logistic regression analyses were performed. Univariate analysis showed that adolescents with a PD and self-harm had (1) an older age at hospitalization (p < 0.01); (2) experienced physical and sexual abuse (p = 0.05, and p < 0.01, respectively); (3) ADHD (p = 0.05); (4) a greater number of SA (p < 0.01); and (5) probability of being a major NSSI patient (>20 lifetime NSSI episodes) (p < 0.01). After multivariate stratified analysis, the results indicated that an older age, and particularly major NSSI status were predictors of PD diagnosis. Early identification and a better understanding of the characteristics of adolescent PDs can assist clinicians in intervening earlier and developing more rational treatment strategies to reduce the long-term effects of PDs. Full article
(This article belongs to the Special Issue Dissecting the Relationship between Personality Disorders and Suicide)
Show Figures

Figure 1

18 pages, 1804 KiB  
Article
Risk of Suicidal Behavior in Children and Adolescents Exposed to Maltreatment: The Mediating Role of Borderline Personality Traits and Recent Stressful Life Events
by Laia Marques-Feixa, Jorge Moya-Higueras, Soledad Romero, Pilar Santamarina-Pérez, Marta Rapado-Castro, Iñaki Zorrilla, María Martín, Eulalia Anglada, María José Lobato, Maite Ramírez, Nerea Moreno, María Mayoral, María Marín-Vila, Bárbara Arias, Lourdes Fañanás and EPI-Young Stress GROUP
J. Clin. Med. 2021, 10(22), 5293; https://0-doi-org.brum.beds.ac.uk/10.3390/jcm10225293 - 14 Nov 2021
Cited by 10 | Viewed by 5480
Abstract
Childhood maltreatment (CM) is associated with increased non-suicidal self-injury (NSSI) and suicidal behavior (SB), independently of demographic and mental health conditions. Self-Trauma Theory and Linehan’s Biopsychosocial Model might explain the emergence of Borderline Personality Disorder (BPD) symptoms as mediators of the association between [...] Read more.
Childhood maltreatment (CM) is associated with increased non-suicidal self-injury (NSSI) and suicidal behavior (SB), independently of demographic and mental health conditions. Self-Trauma Theory and Linehan’s Biopsychosocial Model might explain the emergence of Borderline Personality Disorder (BPD) symptoms as mediators of the association between CM and the risk of SB. However, little is known regarding such relationships when the exposure is recent for young persons. Here, we study 187 youths aged 7–17, with or without mental disorders. We explore CM experiences (considering the severity and frequency of different forms of neglect and abuse), recent stressful life events (SLEs), some BPD traits (emotion dysregulation, intense anger and impulsivity), and the risk of SB (including NSSI, suicide threat, suicide ideation, suicide plan and suicide attempt). We study the direct and mediating relationships between these variables via a structural equation analysis using the statistical software package EQS. Our findings suggest that youths exposed to more severe/frequent CM have more prominent BPD traits, and are more likely to have experienced recent SLEs. In turn, BPD traits increase the risk of SLEs. However, only emotion dysregulation and recent SLEs were found to be correlated with SB. Therefore, targeted interventions on emotion dysregulation are necessary to prevent NSSI or SB in children and adolescents exposed to CM, as is the minimization of further SLEs. Full article
(This article belongs to the Special Issue Dissecting the Relationship between Personality Disorders and Suicide)
Show Figures

Figure 1

11 pages, 287 KiB  
Article
Medically Serious Suicide Attempts in Personality Disorders
by Marta Quesada-Franco, Luis Pintor-Pérez, Constanza Daigre, Enrique Baca-García, Josep Antoni Ramos-Quiroga and María Dolores Braquehais
J. Clin. Med. 2021, 10(18), 4186; https://0-doi-org.brum.beds.ac.uk/10.3390/jcm10184186 - 16 Sep 2021
Cited by 1 | Viewed by 1899
Abstract
Medically serious suicide attempts (MSSA) represent a subgroup of clinically heterogeneous suicidal behaviors very close to suicides. Personality disorders (PD) are highly prevalent among them, together with affective and substance use disorders. However, few studies have specifically analyzed the role of PD in [...] Read more.
Medically serious suicide attempts (MSSA) represent a subgroup of clinically heterogeneous suicidal behaviors very close to suicides. Personality disorders (PD) are highly prevalent among them, together with affective and substance use disorders. However, few studies have specifically analyzed the role of PD in MSSA. These suicide attempts (SA) are usually followed by longer hospitalization periods and may result in severe physical and psychological consequences. The aim of this study is to compare the profile of MSSA patients with and without PD. MSSA were defined according to Beautrais ‘criteria, but had to remain hospitalized ≥48 h. Overall, 168 patients from two public hospitals in Barcelona were evaluated during a three-year period. Mean hospital stay was 23.68 (standard deviation (SD) = 41.14) days. Patients with PD (n = 69) were more likely to be younger, female, make the first and the most serious SA at a younger age, reported recent stressful life-events and more frequently had previous suicide attempts compared to those without PD. However, no differences were found with regards to comorbid diagnoses, current clinical status, features of the attempt, or their impulsivity and hopelessness scores. Therefore, focusing on the subjective, qualitative experiences related to MSSA among PD patients may increase understanding of the reasons contributing to these attempts in order to improve prevention strategies in the future. Full article
(This article belongs to the Special Issue Dissecting the Relationship between Personality Disorders and Suicide)
12 pages, 677 KiB  
Article
Aggression, Impulsivity and Suicidal Behavior in Depressive Disorders: A Comparison Study between New York City (US), Madrid (Spain) and Florence (Italy)
by Javier-David Lopez-Morinigo, Maura Boldrini, Valdo Ricca, Maria A. Oquendo and Enrique Baca-García
J. Clin. Med. 2021, 10(14), 3057; https://0-doi-org.brum.beds.ac.uk/10.3390/jcm10143057 - 09 Jul 2021
Cited by 2 | Viewed by 2279
Abstract
The association of aggression and impulsivity with suicidal behavior (SB) in depression may vary across countries. This study aimed (i) to compare aggression and impulsivity levels, measured with the Brown-Goodwin Scale (BGS) and the Barratt Impulsivity Scale (BIS), respectively, between New York City [...] Read more.
The association of aggression and impulsivity with suicidal behavior (SB) in depression may vary across countries. This study aimed (i) to compare aggression and impulsivity levels, measured with the Brown-Goodwin Scale (BGS) and the Barratt Impulsivity Scale (BIS), respectively, between New York City (NYC) (US), Madrid (Spain) and Florence (Italy) (ANOVA); and (ii) to investigate between-site differences in the association of aggression and impulsivity with previous SB (binary logistic regression). Aggression scores were higher in NYC, followed by Florence and Madrid. Impulsivity levels were higher in Florence than in Madrid or NYC. Aggression and impulsivity scores were higher in suicide attempters than in non-attempters in NYC and in Madrid. SB was associated with aggression in NYC (OR 1.12, 95% CI 1.07–1.16; p < 0.001) and in Florence (OR 1.11, 95% CI 1.01–1.22; p = 0.032). Impulsivity was linked with SB in NYC (OR 1.01, 95% CI 1.00–1.02; p < 0.001) and in Madrid (OR 1.03, 95% CI 1.02–1.05; p < 0.001). The higher suicide rates in NYC, compared to Madrid or Florence, may be, in part, explained by these cross-cultural differences in the contribution of aggression-impulsivity to SB, which should be considered by future research on SB prevention. Full article
(This article belongs to the Special Issue Dissecting the Relationship between Personality Disorders and Suicide)
Show Figures

Figure 1

Review

Jump to: Research

14 pages, 412 KiB  
Review
Understanding the Influence of Personality Traits on Risk of Suicidal Behaviour in Schizophrenia Spectrum Disorders: A Systematic Review
by Manuel Canal-Rivero, Rosa Ayesa-Arriola, Esther Setién-Suero, Benedicto Crespo-Facorro, Celso Arango, Rina Dutta and Javier-David Lopez-Morinigo
J. Clin. Med. 2021, 10(19), 4604; https://0-doi-org.brum.beds.ac.uk/10.3390/jcm10194604 - 08 Oct 2021
Cited by 1 | Viewed by 2391
Abstract
Risk of suicidal behaviour (SB) in schizophrenia spectrum disorders (SSD) is a major concern, particularly in early stages of the illness, when suicide accounts for a high number of premature deaths. Although some risk factors for SB in SSD are well understood, the [...] Read more.
Risk of suicidal behaviour (SB) in schizophrenia spectrum disorders (SSD) is a major concern, particularly in early stages of the illness, when suicide accounts for a high number of premature deaths. Although some risk factors for SB in SSD are well understood, the extent to which personality traits may affect this risk remains unclear, which may have implications for prevention. We conducted a systematic review of previous studies indexed in MEDLINE, PsycINFO and Embase examining the relationship between personality traits and SB in samples of patients with SSD. Seven studies fulfilled predetermined selection criteria. Harm avoidance, passive-dependent, schizoid and schizotypal personality traits increased the risk of SB, while self-directedness, cooperativeness, excluding persistence and self-transcendence acted as protective factors. Although only seven studies were retrieved from three major databases after applying predetermined selection criteria, we found some evidence to support that personality issues may contribute to SB in patients with SSD. Personality traits may therefore become part of routine suicide risk assessment and interventions targeting these personality-related factors may contribute to prevention of SB in SSD. Full article
(This article belongs to the Special Issue Dissecting the Relationship between Personality Disorders and Suicide)
Show Figures

Figure 1

Back to TopTop