80 Years since Hans Spemann - Modern Approaches in Experimental Embryology

A special issue of Journal of Developmental Biology (ISSN 2221-3759).

Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 529

Special Issue Editor

Howard University College of Medicine, Dept. of Anatomy, 520 W St. NW, Washington, DC 20059, USA
Interests: muscle; embryology; development; heart; head

Special Issue Information

Dear Colleagues,

In 2021, it will have been eighty years since Hans Spemann passed, and 85 years since his publication of Experimentelle Beiträge zu einer Theorie der Entwicklung (1936; Embryonic Development and Induction), where he summarized his research. Hans Spemann was a German embryologist who won the Nobel Prize in Physiology or Medicine (1935) for his description of ‘embryonic induction’. Embryonic induction is a process by which parts of the embryo direct the development of cell groups into particular tissues and organs. Spemann’s concept of induction was based on decades of research into early newt development. Since then, advances in developmental biology have resulted in more detailed understanding of developmental patterning. Other organisms became models to study development (e.g., Xenopus, Ambystoma, Danio, Mus, and more recently Ciona) but for many decades, surgical manipulation (ablation, grafting) remained the main way of studying development. However, it is now possible to follow cell lineages by designing markers/reporters, to visualize gene expression (in situ hybridization) or protein presence (antibody staining), and even manipulate genes and gene expression (e.g., morpholinos, CRISPR/Cas9). Other techniques (e.g., whole-genome and singe-cell sequencing) have opened new ways of analyzing what is happening at different stages of development. These methods and/or a combination of these and others have enabled as yet unparalleled detail during the investigation of induction and differentiation of cells, tissues, and organs. This Special Issue of the Journal of Developmental Biology will provide an overview of the current standing in methodology for studying development and developmental mechanisms. Additionally, it will highlight the directions for future research. Contributions can be reviews as well as research papers covering topics of model and non-model organism research.

Dr. Janine M. Ziermann
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Developmental Biology is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • development
  • induction
  • CRISPR
  • cell lineage
  • progenitor
  • sequencing
  • lineage tracing
  • visualization

Published Papers

There is no accepted submissions to this special issue at this moment.
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