Special Issue "Biomimetic Materials for Regenerative Medicine"
A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).
Deadline for manuscript submissions: closed (31 March 2017).
Interests: biomaterials; biomimetic materials; hydrogels; peptide functionalization; scaffold design; spatial patterning; controlled release; tissue engineering; regenerative medicine
Tissue engineering and regenerative medicine have great therapeutic potential but, to date, have had only limited application in the clinic. For example, many biologically active molecules, such as protein growth factors, demonstrate effective results in preclinical animal studies but fail in human clinical trials. Further, expansion of cells in vitro can lead to changes in cell phenotype. As one approach to address these problems, biomimicry can be used to engineer biomaterials that aim to replicate the form and function of biological tissues, based on the hypotheses that these materials can improve tissue regeneration directly or that they can serve as better scaffolds for cells in tissue engineering approaches. The term biomimicry itself is derived from the ancient Greek bios, meaning “life”, and mimesis, meaning “imitation”. Thus, biomimetic materials can imitate their biological counterparts in a number of ways, including both structural and mechanical properties as well as chemical and biological cues. Biomimetic materials systems are often naturally derived or combine synthetic polymers with bioactive components to balance control of material properties with the ability to influence cellular behaviour. Materials functionalized with ligands for cell-surface receptors are particularly interesting, as these materials directly impact cellular interactions with the biomimetic materials. Further, the spatial arrangement of these ligands, the topography of the material, and the available mechanisms of mass transport can all affect the cellular response to these materials. Both in vitro and in vivo studies highlight the potential of biomimetic materials in the field of regenerative medicine. In this Special Issue, we welcome contributions spanning the field, from novel materials development to functional demonstrations in preclinical models.
Prof. Dr. Jennifer Patterson
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Tissue engineering
- Regenerative medicine
- Extracellular matrix
- Structural and mechanical properties
- Mass transport
- Controlled release
- Spatial patterning
- Biochemical modifications