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Metabolic Regulation of the Host-Fungus Interaction
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Metabolic Regulation of the Host-Fungus Interaction

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Cell Biology, Metabolism and Physiology".

Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 9853

Special Issue Editor

Dr. Agostinho Carvalho

E-Mail Website
Guest Editor
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal
Interests: host–fungus interactions; antifungal immunity; genetics of susceptibility; personalized medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The reprogramming of cellular metabolism is recognized as a fundamental mechanism through which immune cells meet the energetic needs during host defense against invading pathogens. Fungal sensing by myeloid cells triggers the reprogramming of host cell metabolism in order to support antimicrobial functions and the production of cytokines and other inflammatory mediators. In turn, fungal pathogens have evolved complex virulence strategies to withstand the host immune response. Although the fine-tuned regulation of the host and fungal cellular metabolism contributes to the outcome of fungal infection, how these processes are regulated remains poorly studied. A better understanding of these processes is expected to pave the way toward alternative diagnostic and therapeutic strategies based on the reorientation of host and/or fungal metabolism. In this Special Issue dedicated to the “Metabolic Regulation of Host–Fungus Interaction”, we invite you to submit research articles or review articles related to the regulatory crosstalk between the host and fungal metabolism and antifungal immunity, novel metabolism-mediated mechanisms of pathogenesis of fungal disease, the diagnostic and therapeutic potential of metabolic targets, and current and emerging approaches to study metabolism in fungal infection.

Dr. Agostinho Carvalho
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (3 papers)

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Research

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14 pages, 1461 KiB  
Article
Aspergillus Metabolome Database for Mass Spectrometry Metabolomics
by Alberto Gil-de-la-Fuente, Maricruz Mamani-Huanca, María C. Stroe, Sergio Saugar, Alejandra Garcia-Alvarez, Axel A. Brakhage, Coral Barbas and Abraham Otero
J. Fungi 2021, 7(5), 387; https://0-doi-org.brum.beds.ac.uk/10.3390/jof7050387 - 15 May 2021
Cited by 6 | Viewed by 3050
Abstract
The Aspergillus Metabolome Database is a free online resource to perform metabolite annotation in mass spectrometry studies devoted to the genus Aspergillus. The database was created by retrieving and curating information on 2811 compounds present in 601 different species and subspecies of [...] Read more.
The Aspergillus Metabolome Database is a free online resource to perform metabolite annotation in mass spectrometry studies devoted to the genus Aspergillus. The database was created by retrieving and curating information on 2811 compounds present in 601 different species and subspecies of the genus Aspergillus. A total of 1514 scientific journals where these metabolites are mentioned were added as meta-information linked to their respective compounds in the database. A web service to query the database based on m/z (mass/charge ratio) searches was added to CEU Mass Mediator; these queries can be performed over the Aspergillus database only, or they can also include a user-selectable set of other general metabolomic databases. This functionality is offered via web applications and via RESTful services. Furthermore, the complete content of the database has been made available in .csv files and as a MySQL database to facilitate its integration into third-party tools. To the best of our knowledge, this is the first database and the first service specifically devoted to Aspergillus metabolite annotation based on m/z searches. Full article
(This article belongs to the Special Issue Metabolic Regulation of the Host-Fungus Interaction)
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21 pages, 2291 KiB  
Article
Transcriptomic Profiling of Populus Roots Challenged with Fusarium Reveals Differential Responsive Patterns of Invertase and Invertase Inhibitor-Like Families within Carbohydrate Metabolism
by Tao Su, Biyao Zhou, Dan Cao, Yuting Pan, Mei Hu, Mengru Zhang, Haikun Wei and Mei Han
J. Fungi 2021, 7(2), 89; https://0-doi-org.brum.beds.ac.uk/10.3390/jof7020089 - 27 Jan 2021
Cited by 9 | Viewed by 2878
Abstract
Fusarium solani (Fs) is one of the notorious necrotrophic fungal pathogens that cause root rot and vascular wilt, accounting for the severe loss of Populus production worldwide. The plant–pathogen interactions have a strong molecular basis. As yet, the genomic information and transcriptomic profiling [...] Read more.
Fusarium solani (Fs) is one of the notorious necrotrophic fungal pathogens that cause root rot and vascular wilt, accounting for the severe loss of Populus production worldwide. The plant–pathogen interactions have a strong molecular basis. As yet, the genomic information and transcriptomic profiling on the attempted infection of Fs remain unavailable in a woody model species, Populus trichocarpa. We used a full RNA-seq transcriptome to investigate the molecular interactions in the roots with a time-course infection at 0, 24, 48, and 72 h post-inoculation (hpi) of Fs. Concomitantly, the invertase and invertase inhibitor-like gene families were further analyzed, followed by the experimental evaluation of their expression patterns using quantitative PCR (qPCR) and enzyme assay. The magnitude profiles of the differentially expressed genes (DEGs) were observed at 72 hpi inoculation. Approximately 839 genes evidenced a reception and transduction of pathogen signals, a large transcriptional reprogramming, induction of hormone signaling, activation of pathogenesis-related genes, and secondary and carbohydrate metabolism changes. Among these, a total of 63 critical genes that consistently appear during the entire interactions of plant–pathogen had substantially altered transcript abundance and potentially constituted suitable candidates as resistant genes in genetic engineering. These data provide essential clues in the developing new strategies of broadening resistance to Fs through transcriptional or translational modifications of the critical responsive genes within various analyzed categories (e.g., carbohydrate metabolism) in Populus. Full article
(This article belongs to the Special Issue Metabolic Regulation of the Host-Fungus Interaction)
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Review

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16 pages, 1557 KiB  
Review
Zinc at the Host–Fungus Interface: How to Uptake the Metal?
by Lucas Weba Soares, Alexandre Melo Bailão, Célia Maria de Almeida Soares and Mirelle Garcia Silva Bailão
J. Fungi 2020, 6(4), 305; https://0-doi-org.brum.beds.ac.uk/10.3390/jof6040305 - 21 Nov 2020
Cited by 14 | Viewed by 3309
Abstract
Zinc is an essential nutrient for all living organisms. However, firm regulation must be maintained since micronutrients also can be toxic in high concentrations. This notion is reinforced when we look at mechanisms deployed by our immune system, such as the use of [...] Read more.
Zinc is an essential nutrient for all living organisms. However, firm regulation must be maintained since micronutrients also can be toxic in high concentrations. This notion is reinforced when we look at mechanisms deployed by our immune system, such as the use of chelators or membrane transporters that capture zinc, when threatened with pathogens, like fungi. Pathogenic fungi, on the other hand, also make use of a variety of transporters and specialized zinc captors to survive these changes. In this review, we sought to explain the mechanisms, grounded in experimental analysis and described to date, utilized by pathogenic fungi to maintain optimal zinc levels. Full article
(This article belongs to the Special Issue Metabolic Regulation of the Host-Fungus Interaction)
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