Dear Colleagues,

Inorganic polyphosphates (polyPs) are the linear polymers of orthophosphoric acid, varying in the number of phosphate residues linked by the energy-rich phosphoanhydride bonds. Polyphosphates are an essential component in living cells. Knowledge of polyP metabolism in eukaryotes is necessary for understanding the molecular mechanisms of polyP metabolism in humans and the development of new approaches for treating bone and cardiovascular diseases associated with impaired polyphosphate metabolism. Yeast cells represent a rational experimental model for this research. Yeasts possess a multicomponent system of polyP metabolism, including the proteins of the VTC complex and polyphosphatases with different structures, properties, cellular localizations, and functions. Besides phosphate storage, polyPs in yeast participate in energy metabolism, stress adaptation, cell cycle regulation, and the virulence of pathogenic yeast species.

Further studies of the metabolism and functional role of polyPs are important in order to develop our understanding of a wide range of regulatory processes in yeast cells, including phosphorus homeostasis, adaptation to stresses, and host–pathogen interaction. This Special Issue of the Journal of Fungi will present reviews and research articles on the topic of “Inorganic Polyphosphate Metabolism and Functions in Yeasts”.

Dr. Tatiana Kulakovskaya
Guest Editor

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• yeast
• polyphosphate
• polyphosphatase
• stress
• phosphate homeostasis
• subcellular compartment
• cell ultrastructure
• virulence
• Vtc4