ATP Release in Health and Disease

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 1207

Special Issue Editors

Department of Medicine, Université de Montréal, and Centre de recherche, Centre hospitalier de l'Université de Montréal, (CRCHUM), Montréal, QC, Canada
Interests: mechanosensitive ATP release; purinergic signaling; lung epithelial cells; ATP imaging; mucus rheology; cystic fibrosis; cell volume regulation
Special Issues, Collections and Topics in MDPI journals
Department of Medicine, Université de Montréal, and Centre de recherche, Centre hospitalier de l'Université de Montréal, (CRCHUM), Montréal, QC, Canada
Interests: mechanosensitive ATP release; purinergic signaling; lung epithelial cells; ATP imaging; mucus rheology; cystic fibrosis; cell volume regulation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The release of cellular adenosine triphosphate (ATP), along with other nucleotides, triggers the purinergic signaling system that is expressed in virtually all types of cells and tissues. By autocrine/paracrine stimulation of purinergic receptors, released extracellular nucleotides regulate numerous physiological processes, including neurotransmission, mucocilliary clearance in the lungs, thrombocyte aggregation, neutrophils migration, local blood flow, and bone remodeling. ATP release is also associated with the pathogenesis of a number of diseases and clinical complications, including cancer, acute respiratory distress syndrome, and ventilator-induced lung injury. There is increasing interest in the therapeutic potential of purinergic compounds in a wide range of disease conditions.

Despite significant advances in the molecular, functional, and pharmacological characterization of numerous purinoreceptors as well as ectoenzymes involved in the metabolism and conversion of extracellular nucleotides, the initiating step of the purinergic signaling—the release of ATP—remains least understood. Multiple release pathways/mechanisms have been proposed, including the exocytosis of ATP-loaded vesicles, as well as a variety of conductive pathways, including bacterial toxins. Even though much progress has been made, in many cases there is still an active debate about the precise nature of the specific conductive pathways of the release, their molecular identity, biophysical characteristics, and physiological regulation. Recently, there is also more appreciation of ATP release resulting from cell membrane injury and cell lysis as important contributors to normal cell signaling.

This Special Issue intends to present the latest developments in the field, covering multiple areas of ATP release research and different points of view regarding the underlying mechanisms. We will welcome original research, reviews, and short reports on various aspects of ATP release as well as technical reports on novel or improved experimental approaches or imaging tools for studying cellular ATP release.

Prof. Dr. Ryszard Grygorczyk
Dr. Francis Boudreault
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ATP secretion
  • purinergic signaling
  • mechano-sensation
  • luciferase

Published Papers

There is no accepted submissions to this special issue at this moment.
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