Focal Chondral Defects
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".
Deadline for manuscript submissions: closed (28 February 2021) | Viewed by 34285
Special Issue Editors
Interests: orthopedics; traumatology; meta-analysis; medical statistics; regenerative medicine; biomechanics
Special Issues, Collections and Topics in MDPI journals
2. School of Pharmacy and Bioengineering, Keele University Faculty of Medicine, Thornburrow Drive, Stoke on Trent ST4 7QB, UK
3. Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Fisciano, Italy
Interests: orthopaedic
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Focal chondral defects are a common cause of joint complaints and impairment, affecting negatively the quality of life of patients. Given the poor self-healing capability of the cartilage, isolated chondral and osteochondral defects are a difficult clinical challenge, especially for younger patients, for whom alternatives such as partial or total knee arthroplasty are rarely advised. Focal chondral defects left untreated, or managed sub-optimally, can lead to osteoarthritis over time. Thus, a prompt and effective treatment may be necessary. Despite the progress made in the clinical sciences, no consensus regarding the best treatment for focal chondral defects has been reached. Advances in cell-based and delivery techniques for the repair of focal chondral defects have yielded much interest, a broad range of studies, and applications in orthopaedic surgery. However, the limited capacity of damaged cartilage to regenerate and the potential morbidity associated with implanting or transferring bone and cartilage make regenerative medicine an attractive alternative. The future of managing cartilage defects is supposed to lie in providing biologic solutions through cartilage regeneration and tissue engineering. The purpose of this Special Issue is to investigate current strategies and future perspectives for the management of focal chondral defects of the hip, knee, and ankle.
Dr. Filippo Migliorini
Guest Editor
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Keywords
- focal chondral defects
- cartilage healing
- regenerative medicine