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Marine Drugs
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Advanced Mass Spectrometry in the Chemistry and Biology of Bioactive...
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Advanced Mass Spectrometry in the Chemistry and Biology of Bioactive Marine Natural Products

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (15 March 2021) | Viewed by 3748

Special Issue Editors

Prof. Dr. Maria Chiara Monti

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Guest Editor
Department of Pharmacy, University of Naples 'Federico II', Via Tommaso De Amicis 95, 80131 Naples, Italy
Interests: proteomics; functional proteomics; metabolomics; analytical chemistry; small-molecules/proteins interactions; marine-inspired compounds
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Raffaele Riccio

E-Mail Website
Guest Editor
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, Fisciano, Italy
Interests: chemistry of bioactive natural products from marine and terrestrial sources; approaches to the stereochemical determination of organic molecules by NMR and computational methods; target identification of bioactive natural products and investigation of ligand–receptor interactions by NMR and MS techniques, combined with computational tools
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

At present, mass spectrometry (MS) technology is continuing to improve dramatically, and MS advanced strategies are becoming easily available in the majority of laboratories. The basic characteristics behind these advancements are MS resolution, quantitative accuracy, and improving data processing skills. Mainly in the field of bioactive marine natural products (MNP), MS progress helps to discover accurate chemical structures’ determination together with MNP quantitative evaluation in complex raw mixtures; in addition, biological events induced by MNP can be traced by comprehensively measuring the various changes in biomolecular dynamics thanks to omics-based strategies. Thus, as the Guest Editors, we would like to invite scientists to publish their developments in the field of bioactive marine natural products achieved by innovative MS-based techniques both from a chemical and a biological viewpoint.

Prof. Maria Chiara Monti
Prof. Raffaele Riccio
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Mass spectrometry
  • Proteomics
  • Metabolomics
  • Structure identification
  • Bioanalysis
  • Ligand–receptor interactions

Published Papers (1 paper)

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Research

18 pages, 2226 KiB  
Article
A Metabolomics Exploration of the Sexual Phase in the Marine Diatom Pseudo-nitzschia multistriata
by Federica Fiorini, Camilla Borgonuovo, Maria Immacolata Ferrante and Mark Brönstrup
Mar. Drugs 2020, 18(6), 313; https://0-doi-org.brum.beds.ac.uk/10.3390/md18060313 - 14 Jun 2020
Cited by 16 | Viewed by 3250
Abstract
Pseudo-nitzschia multistriata is a planktonic marine diatom with a diplontic life cycle comprising a short sexual phase, during which gametes are produced following the encounter of two diploid cells of opposite mating type (MT). Gene expression studies have highlighted the presence of substantial [...] Read more.
Pseudo-nitzschia multistriata is a planktonic marine diatom with a diplontic life cycle comprising a short sexual phase, during which gametes are produced following the encounter of two diploid cells of opposite mating type (MT). Gene expression studies have highlighted the presence of substantial changes occurring at the onset of sexual reproduction. Herein, we have hypothesized that the amount and nature of cellular metabolites varies along the mating process. To capture the metabolome of Pseudo-nitzschia multistriata at different harvesting times in an unbiased manner, we undertook an untargeted metabolomics approach based on liquid chromatography–tandem mass spectrometry. Using three different extraction steps, the method revealed pronounced differences in the metabolic profiles between control cells in the vegetative phase (MT+ and MT−) and mixed strains of opposite MTs (cross) undergoing sexual reproduction. Of the 2408 high-quality features obtained, 70 known metabolites could be identified based on in-house libraries and online databases; additional 46 features could be classified by molecular networking of tandem mass spectra. The reduction of phytol detected in the cross can be linked to the general downregulation of photosynthesis during sexual reproduction observed elsewhere. Moreover, the role of highly regulated compounds such as 7-dehydrodesmosterol, whose changes in abundance were the highest in the experiment, oleamide, ectoine, or trigonelline is discussed. Full article
(This article belongs to the Special Issue Advanced Mass Spectrometry in the Chemistry and Biology of Bioactive Marine Natural Products)
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