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Current Developments in Additive Manufacturing for Tissue Engineering and Regenerative Medicine

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (31 January 2021) | Viewed by 2417

Special Issue Editors


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Guest Editor
1. School of Mechanical and Manufacturing Engineering, Dublin City University, D09 NA55 Dublin, Ireland
2. Centre for Medical Engineering Research, Dublin City University, D09 NA55 Dublin, Ireland
Interests: biomaterials; tissue engineering; tissue regeneration; drug delivery; biomedical engineering
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
School of Mechanical and Manufacturing Engineering, Dublin City University, D09 NA55 Dublin, Ireland
Interests: cartilage; tissue engineering; scaffolds; bone repair; biomaterials; bioprinting
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
School of Pharmacy, Queen’s University Belfast, 97 Lisburn Rd., Belfast BT9 7BL, UK
Interests: nanomedicine; gene therapy; nucleic acids; oncology; wound healing and mRNA and DNA vaccination
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We would like to invite you to contribute a short communication, full article or review to this Special Issue, entitled “Current Developments in Additive Manufacturing for Tissue Engineering and Regenerative Medicine”.

Additive manufacturing, often referred to as three-dimensional (3D) printing, has revolutionised traditional medical device development processes and treatment strategies. The adaptation of innovative additive manufacturing techniques for tissue engineering and regenerative medicine has enabled the fabrication of scaffolds that closely mimic the physiochemical properties, architectural complexity and function of native organs and tissues. For example, one can fabricate complex patient-specific biomedical devices designed and tailored to the anatomy of the patient. Equally, one can also consider the development of patient-specific drug-delivery systems that can be custom-designed and fabricated using additive manufacturing techniques to provide on-demand delivery of medication exactly at the required anatomical location. Many additive manufacturing techniques have also been utilised to 3D-print biomaterials and medical devices that enable the regeneration of complex biological tissues, such as muscles and nerves and even the regeneration of organs.

The focus of this Special Issue of Materials is to provide a forum for original research articles, as well as critical reviews related to the progress that has been made in this field during the last decade. The Special Issue will illustrate where we are at this time, expand on results, highlight the newest advances in the development of compatible additive manufacturing processes and the design of novel materials that are capable of producing biomimetic scaffolds and report on regulatory issues, near future possibilities and the limitations of this technology as used in tissue engineering and regenerative medicine.

Prof. Dr. Nicholas Dunne
Dr. Tanya Levingstone
Prof. Dr. Helen McCarthy
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Bioinks and biomaterials
  • Bioprinting
  • Biofabrication
  • Stereolithography
  • Digital light processing 3D Printing
  • Extrusion-based printing
  • Direct-write and melt electrospinning
  • New additive manufacturing materials and methods
  • 3D tissue culture models
  • Regulatory issues
  • Drug delivery
  • Tissue and organ regeneration

Published Papers (1 paper)

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Research

10 pages, 2254 KiB  
Article
Dentin Phosphophoryn-Derived Peptide Promotes Odontoblast Differentiation In Vitro and Dentin Regeneration In Vivo
by Bayarchimeg Altankhishig, Mohammad Ali Akbor Polan, Youjing Qiu, Md Riasat Hasan and Takashi Saito
Materials 2021, 14(4), 874; https://0-doi-org.brum.beds.ac.uk/10.3390/ma14040874 - 12 Feb 2021
Cited by 6 | Viewed by 1749
Abstract
The purpose of the present study was to investigate the effect of a peptide (i.e., SESDNNSSSRGDASYNSDES) derived from dentin phosphophoryn (DPP) with arginine-glycine-aspartic acid (RGD) motifs on odontoblast differentiation in vitro and to compare it with calcium hydroxide—a material used conventionally for vital [...] Read more.
The purpose of the present study was to investigate the effect of a peptide (i.e., SESDNNSSSRGDASYNSDES) derived from dentin phosphophoryn (DPP) with arginine-glycine-aspartic acid (RGD) motifs on odontoblast differentiation in vitro and to compare it with calcium hydroxide—a material used conventionally for vital pulp therapy—in terms of reparative dentin formation and pulp inflammation in vivo. Alkaline phosphatase activity assay and alizarin red S staining were performed to evaluate odontoblast-differentiation in cell culturing experiments. To observe the reparative dentin formation and pulp inflammation animal experiment was performed and examined by histological methods. The difference between the experimental group and the control group was analyzed statistically using a one-way ANOVA test. The results revealed that the DPP-derived RGD-containing peptide triggered odontoblast differentiation and mineralization in vitro. In rats undergoing direct pulp capping, the DPP-derived RGD-containing peptide was found to induce intensively formed reparative dentin with high compactness at week 4. On histological and morphometrical examinations, a smaller degree of pulpitis was observed in the specimens treated with the peptide than in those treated with calcium hydroxide. This study suggests that the DPP-derived RGD-containing peptide is a biocompatible, biodegradable and bioactive material for dentin regeneration. Full article
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