Special Issue "Biofunctionalized Scaffold in Regenerative Medicine-Series II"

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editors

Dr. Francesca Diomede
E-Mail Website
Guest Editor
Department of Medical, Oral and Biotechnological Sciences, University “G. d’Annunzio”, Chieti-Pescara, Chieti, Italy
Interests: stem cells; oral MSCs; biomaterials; 3D cultures; scaffold; extracellular vesicles (EVs); regenerative medicine; tissue engineering; scaffold; bioprinting; dentistry
Special Issues, Collections and Topics in MDPI journals
Dr. Jacopo Pizzicanella
E-Mail Website
Guest Editor
“Ss. Annunziata” Hospital, ASL 02 Lancino-Vasto-Chieti, Chieti, Italy
Interests: stem cells; oral MSCs; biomaterials; regenerative medicine; tissue regeneration; scaffold; bioprinting
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The use of a biofunctionalized scaffold with cells and/or soluble factors has emerged as a promising approach in the field of regenerative medicine. A biomaterial refers to a matrix that provides a specific environment and supports growth and development. An ideal scaffold must be biocompatible and nontoxic, and should improve cell viability, cell adhesion, and proliferation. Different scaffolds can be combined with cells, such as mesenchymal stem cells (MSCs), that can promote bone regeneration through differentiation towards the osteogenic lineage or the release of specific soluble factors, or scaffolds can be primed with soluble molecules, including growth factors that can be delivered in the environment, performing therapeutic actions. In recent years, many isolation and culture technologies have been proposed for obtaining a large number of MSCs. These technologies have promoted the application of stem cells in research into disease mechanisms and clinical therapy. MSCs have their own advantages for therapeutic applications, avoiding the risks of immune rejection, directional regulation, and ethical controversy.

Better evaluating the tissue regeneration in scaffold/stem cell models, determining if the emerging imaging technologies fulfill all of the requirements for stem cell therapy research at present, and realizing their improvement and the development of multimodal molecular imaging systems will effectively promote the understanding of stem cell therapy biology and its mechanisms.

The aim of this Special Issue is to provide an overview of ongoing scientific research to better understand the molecular mechanisms involved in tissue regeneration and the evaluation of the aptitude of biofunctionalized scaffolds for future clinical applications. In vitro and/or in vivo studies could have a substantial impact on the development of stem cell-based regeneration strategies and in the identification of key biological regulation processes.

Dr. Francesca Diomede
Dr. Jacopo Pizzicanella
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • regenerative medicine
  • tissue engineering
  • mesenchymal stem cells
  • 3D-construct

Published Papers

This special issue is now open for submission.
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