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Advances in Biomaterials of Oral and Maxillofacial Surgery and Implant Dentistry

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A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (20 May 2022) | Viewed by 7321

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Dr. Domenico Dalessandri

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Dental School, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, 25121 Brescia, Italy
Interests: oral surgery; implant dentistry; restorative dentistry; AI; systematic reviews; 3D imaging; computed tomography
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Dear Colleagues,

Research in oral and maxillofacial surgery and implant dentistry is rapidly developing, creating new generations of biomaterials for guided tissue regeneration and tissue engineering with functional scaffolds and growth factors. Understanding of the bone-implant interface constantly progresses, guiding new evolution in dental osseo-integrated implants design and composition, directed to the development of proactive implants that can help promote desired outcomes. New 3D technologies, from scanners to CAD software and both milling and printing machines, allow researchers to model all these biomaterials in a fully customized shape, taking into consideration the specific architectural and biochemical features of the tissues to be regenerated.

This Special Issue will collect original research papers, both in vivo and in vitro, and comprehensive reviews on different aspects related to the recent updates in maxillofacial research, ranging from biocompatibility assessment methods to the synthesis of functional scaffolds employed in regenerative therapies and the characterization of dental implant geometries and materials, exploring new inter-disciplinary strategies to enhance oral and maxillofacial regenerative and restorative procedures

Prof. Dr. Domenico Dalessandri
Guest Editor

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Keywords

biomechanical simulation
bone substitutes
computer aided design
computer aided manufacturing
dental implants
implantology
maxillofacial surgery
scaffold
tissue engineering

Published Papers (4 papers)

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Research

11 pages, 2259 KiB

Open AccessArticle

Hyaluronic Acid with Bone Substitutes Enhance Angiogenesis In Vivo

by Solomiya Kyyak, Sebastian Blatt, Nadine Wiesmann, Ralf Smeets and Peer W. Kaemmerer

Materials 2022, 15(11), 3839; https://doi.org/10.3390/ma15113839 - 27 May 2022

Cited by 4 | Viewed by 1572

Abstract

Introduction: The effective induction of angiogenesis is directly related to the success of bone-substitute materials (BSM) for maxillofacial osseous regeneration. Therefore, the addition of pro-angiogenic properties to a commercially available bovine bone-substitute material in combination with hyaluronic acid (BSM+) was compared to the same bone-substitute material without hyaluronic acid (BSM) in an in-vivo model. Materials and Methods: BSM+ and BSM were incubated for six days on the chorioallantoic membrane (CAM) of fertilized chicken eggs. Microscopically, the number of vessels and branching points, the vessel area and vessel length were evaluated. Subsequently, the total vessel area and brightness integration were assessed after immunohistochemical staining (H&E, alphaSMA). Results: In the BSM+ group, a significantly higher number of vessels (p < 0.001), branching points (p = 0.001), total vessel area (p < 0.001) as well as vessel length (p = 0.001) were found in comparison to the BSM group without hyaluronic acid. Immunohistochemically, a significantly increased total vessel area (p < 0.001 for H&E, p = 0.037 for alphaSMA) and brightness integration (p = 0.047) for BSM+ in comparison to the native material were seen. Conclusions: The combination of a xenogenic bone-substitute material with hyaluronic acid significantly induced angiogenesis in vivo. This might lead to a faster integration and an improved healing in clinical situations. Full article

(This article belongs to the Special Issue Advances in Biomaterials of Oral and Maxillofacial Surgery and Implant Dentistry)

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15 pages, 5431 KiB

Open AccessArticle

Osseointegration of Zirconia Implants after UV-Light or Cold Atmospheric Plasma Surface Treatment In Vivo

by Lisa Krautwald, Ralf Smeets, Carolin Stolzer, Rico Rutkowski, Linna Guo, Aline Reitmeier, Martin Gosau and Anders Henningsen

Materials 2022, 15(2), 496; https://0-doi-org.brum.beds.ac.uk/10.3390/ma15020496 - 10 Jan 2022

Cited by 6 | Viewed by 1411

Abstract

The influence of UV light and non-thermal plasma on the osseointegration of yttria-stabilized zirconia implants (Y-TZP) comparing the two methods is unclear. The aim of this study was to show the influence of these methods on the osseointegration of dental zirconia implants in an animal model. A total of 54 implants were either untreated, treated with UV light (UV), or non-thermal oxygen plasma for 12 min and inserted into the parietal bones of six domestic pigs. The animals were sacrificed after a healing interval of two, four, and nine weeks. The degree of osseointegration was determined using histomorphometric determination of bone-to-implant contact values (BIC) and the bone-to-implant contact values within the retentive parts of the implants (BAFO). BIC values decreased in all groups after four weeks of healing and re-increased after nine weeks in all groups. BAFO increased significantly over time in all groups. However, there were no statistically significant differences in BIC and BAFO values between the control group and the test groups and over time. Clinical studies may follow to confirm the influence of cold plasma and UV light on the healing and survival of zirconia implants. Full article

(This article belongs to the Special Issue Advances in Biomaterials of Oral and Maxillofacial Surgery and Implant Dentistry)

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20 pages, 8263 KiB

Open AccessArticle

Gene-Activated Matrix with Self-Assembly Anionic Nano-Device Containing Plasmid DNAs for Rat Cranial Bone Augmentation

by Masahito Hara, Yoshinori Sumita, Yukinobu Kodama, Mayumi Iwatake, Hideyuki Yamamoto, Rena Shido, Shun Narahara, Takunori Ogaeri, Hitoshi Sasaki and Izumi Asahina

Materials 2021, 14(22), 7097; https://0-doi-org.brum.beds.ac.uk/10.3390/ma14227097 - 22 Nov 2021

Cited by 1 | Viewed by 1648

Abstract

We have developed nanoballs, a biocompatible self-assembly nano-vector based on electrostatic interactions that arrange anionic macromolecules to polymeric nanomaterials to create nucleic acid carriers. Nanoballs exhibit low cytotoxicity and high transfection efficiently in vivo. This study investigated whether a gene-activated matrix (GAM) composed of nanoballs containing plasmid (p) DNAs encoding bone morphogenetic protein 4 (pBMP4) could promote bone augmentation with a small amount of DNA compared to that composed of naked pDNAs. We prepared nanoballs (BMP4-nanoballs) constructed with pBMP4 and dendrigraft poly-L-lysine (DGL, a cationic polymer) coated by γ-polyglutamic acid (γ-PGA; an anionic polymer), and determined their biological functions in vitro and in vivo. Next, GAMs were manufactured by mixing nanoballs with 2% atelocollagen and β-tricalcium phosphate (β-TCP) granules and lyophilizing them for bone augmentation. The GAMs were then transplanted to rat cranial bone surfaces under the periosteum. From the initial stage, infiltrated macrophages and mesenchymal progenitor cells took up the nanoballs, and their anti-inflammatory and osteoblastic differentiations were promoted over time. Subsequently, bone augmentation was clearly recognized for up to 8 weeks in transplanted GAMs containing BMP4-nanoballs. Notably, only 1 μg of BMP4-nanoballs induced a sufficient volume of new bone, while 1000 μg of naked pDNAs were required to induce the same level of bone augmentation. These data suggest that applying this anionic vector to the appropriate matrices can facilitate GAM-based bone engineering. Full article

(This article belongs to the Special Issue Advances in Biomaterials of Oral and Maxillofacial Surgery and Implant Dentistry)

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9 pages, 980 KiB

Open AccessArticle

Comparison between Tissue Adhesive Cyanoacrylate and Suture for Palatal Fibromucosa Healing: A Randomized Controlled Study

by Carlota Castro-Gaspar, Maria Victoria Olmedo-Gaya, Maria Nuria Romero-Olid, Maria Jesús Lisbona-Gonzalez, Marta Vallecillo-Rivas and Candela Reyes-Botella

Materials 2021, 14(22), 7009; https://0-doi-org.brum.beds.ac.uk/10.3390/ma14227009 - 19 Nov 2021

Cited by 6 | Viewed by 1752

Abstract

Cyanoacrylate tissue adhesive is proposed to promote soft tissue healing in oral surgery and minimize complications (pain, inflammation, and bleeding) associated with wound healing by secondary intention. The objective was to compare cyanoacrylate tissue adhesive (test group) with suture (control group) in terms of postoperative complications, operative time, and wound healing in the palatal donor area after harvesting a de-epithelialized gingival graft. A randomized controlled clinical trial was performed in 24 patients randomly assigned to one of two study groups. Data were gathered on wound bleeding, operative time, postoperative pain, inflammation, hyperesthesia, necrosis, and donor area healing time. Operative time was almost 50% shorter in the tissue adhesive cyanoacrylate group, a significant between-group difference (p = 0.003). Spontaneous bleeding in the donor area during the first 24 h was observed in 11.1% of the tissue adhesive cyanoacrylate group versus 88.9% of the suture group—a significant difference. No significant between-group difference was observed in postoperative pain, inflammation, or degree of healing over time. There were no cases of hyperesthesia or wound necrosis. Utilization of tissue adhesive cyanoacrylate rather than suture in palatal de-epithelialized gingival graft harvesting reduces postoperative bleeding during the first 24 h, as well as the operative time. Full article

(This article belongs to the Special Issue Advances in Biomaterials of Oral and Maxillofacial Surgery and Implant Dentistry)

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